MMP1 protein, human

Known as: matrix metallopeptidase 1 (interstitial collagenase), human, MMP1, EC 3.4.24.7 
Interstitial collagenase (469 aa, ~54 kDa) is encoded by the human MMP1 gene. This protein plays a role in collagenolysis.

Topic mentions per year

Topic mentions per year

1963-2018
0204019632018

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Highly Cited
2001
Highly Cited
2001
Pulmonary emphysema is believed to result from an imbalance between proteolytic enzymes and their inhibitors. Multiple studies… (More)
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Highly Cited
2000
Highly Cited
2000
OBJECTIVE Matrix metalloproteinases (MMPs) are expressed in joint tissues of patients with rheumatoid arthritis (RA) and… (More)
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Highly Cited
2000
Highly Cited
2000
Interleukin (IL-)17 is a T cell-derived pro-inflammatory cytokine produced by RA synovium. We studied the role of IL-17 in the… (More)
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Highly Cited
1999
Highly Cited
1999
BACKGROUND Several recent studies attempted to classify plaques as those prone to cause clinical manifestations (vulnerable… (More)
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Highly Cited
1998
Highly Cited
1998
The aim of this study was to investigate the extracellular degrading proteolytic cascade proteins referred to as matrix… (More)
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Highly Cited
1997
Highly Cited
1997
Membrane type 1 matrix metalloproteinase (MT1-MMP) is expressed on cancer cell membranes and activates the zymogen of MMP-2… (More)
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Highly Cited
1997
Highly Cited
1997
We have shown in a variety of human wounds that collagenase-1 (MMP-1), a matrix metalloproteinase that cleaves fibrillar type I… (More)
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Highly Cited
1996
Highly Cited
1996
Matrix metalloproteinases (MMPs) and interleukin 1 (IL-1) are implicated in inflammation and tissue destruction, where IL-1 is a… (More)
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Highly Cited
1996
Highly Cited
1996
Atherosclerotic plaque rupture may occur when regions of weakened extracellular matrix are subjected to increased mechanical… (More)
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Highly Cited
1990
Highly Cited
1990
Human rheumatoid synovial cells in culture secrete at least three related metalloproteinases that digest extracellular matrix… (More)
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