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COLLAGENASE

Known as: Collagen Degrading Enzyme, Collagenases [Chemical/Ingredient], Collagenases 
Collagenases are enzymes that degrade collagen fibers. These enzymes play an important role in connective tissue metabolism and are produced by… 
National Institutes of Health

Related topics

Related topics

41 relations
Burn injuryCOLLAGENASE 0.25 UNT/MG Topical OintmentCollagenase:CCnc:Pt:Ser:QnDrug Allergy

Narrower (13)

ColH protein, Clostridium histolyticumFN type IV collagenaseInterstitial CollagenaseLiberase

Broader (4)

GelatinasesMetalloendopeptidasesMetalloproteasesmetalloenzyme

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Intracerebral Hemorrhage Models in Rat: Comparing Collagenase to Blood Infusion
Many therapies have shown promise in preclinical stroke studies, but few benefit patients. A greater understanding of stroke… 
Highly Cited
2007
Highly Cited
2007
Increased nanoparticle penetration in collagenase-treated multicellular spheroids
The extracellular matrix of solid tumors presents a transport barrier that restricts nanoparticle penetration, thereby limiting… 
Highly Cited
2004
Highly Cited
2004
Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification.
Collagenase-3 (MMP13), a member of the matrix metalloproteinase (MMP) family of neutral endopeptidases, is expressed in the… 
Highly Cited
1990
Highly Cited
1990
Collagenase-induced intracerebral hemorrhage in rats.
Intracranial bleeding is an important cause of brain masses and edema. To study the pathophysiology of intracerebral hemorrhage… 
Highly Cited
1989
Highly Cited
1989
Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression
We have investigated the effects of ligation of the fibronectin receptor (FnR) on gene expression in rabbit synovial fibroblasts… 
Highly Cited
1986
Highly Cited
1986
Tumor invasion through the human amniotic membrane: Requirement for a proteinase cascade
Highly Cited
1985
Highly Cited
1985
Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts
Cachectin/TNF (tumor necrosis factor), an endotoxin-induced murine macrophage hormone implicated in the pathogenesis of cachexia… 
Highly Cited
1982
Highly Cited
1982
Epithelia suspended in collagen gels can lose polarity and express characteristics of migrating mesenchymal cells
This study of epithelial-mesenchymal transformation and epithelial cell polarity in vitro reveals that environmental conditions… 
Highly Cited
1980
Highly Cited
1980
Metastatic potential correlates with enzymatic degradation of basement membrane collagen
Tumour cells traverse epithelial and endothelial basement membranes during the successive stages of the metastatic process. At… 
Highly Cited
1977
Highly Cited
1977
Endogenous activation of latent collagenase by rheumatoid synovial cells. Evidence for a role of plasminogen activator.
To elucidate the mechanism of synovial damage in rheumatoid arthritis, we studied the activation of latent collagenases released… 
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