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Metalloproteases

Known as: Metallopeptidase, Metalloproteinases, METALLOPROTEASE 
A proteolytic enzyme that uses a metal ion, usually zinc, to catalyze the hydrolysis of peptide bonds. This protease is inhibited by metal chelating… 
National Institutes of Health

Related topics

Related topics

40 relations

Narrower (22)

ADAMTSAMMP protein, Armillaria melleaAstl protein, mouseBJ-PI2 non-hemorrhagic metalloproteinase, Bothrops jararaca

Broader (1)

Endopeptidases
Enzyme GeneHydrolysisIn BloodLMLN gene

Papers overview

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2006
2006
ADAM 28 Is Overexpressed in Human Breast Carcinomas : Implications for Carcinoma Cell Proliferation through Cleavage of Insulin-like Growth Factor Binding Protein-3
A disintegrin and metalloproteinases (ADAMs) are involved in various biological events including cell adhesion, cell fusion… 
2001
2001
On genetics, inflammation, and abdominal aortic aneurysm: can single nucleotide polymorphisms predict the outcome?
The late Professor Russell Ross proposed the “response to injury” hypothesis for the pathogenesis of atherosclerosis ≈25 years… 
2001
2001
Crithidia guilhermei: purification and partial characterization of a 62-kDa extracellular metalloproteinase.
An extracellular metalloproteinase from Crithidia guilhermei, a monoxenic trypanosomatid of insects, was purified 11-fold by… 
2000
2000
Matrix metalloproteinases of human NK cells.
We have previously reported that MMP-2 and MMP-9 are present in rat A-NK cells, and have recently documented that additional MMPs… 
2000
2000
Immunocytochemical detection of MMP-3 and -10 expression in hepatocellular carcinomas.
Structural changes in the extracellular matrix (ECM) are necessary for cell migration during tissue remodeling and tumor invasion… 
1999
1999
Increased serum stromelysin-1 levels in systemic lupus erythematosus: lack of correlation with disease activity.
OBJECTIVE In view of evidence that stromelysin-1 and collagenase-1 are involved in tissue injury in inflammatory joint diseases… 
1991
1991
Zinc Metallopeptidase Inhibitors A Novel Antihypertensive Treatment
Inhibitors of two zinc metallopeptidases, angiotensin I converting enzyme (ACE) and neutral metalloendopeptidase-24.11 (EP-24.11… 
Highly Cited
1988
Highly Cited
1988
Similar effects of adenovirus E1A and glucocorticoid hormones on the expression of the metalloprotease stromelysin.
The stromelysin (sml) gene encodes a secreted protease which degrades components of the extracellular matrix. Transformation of… 
1984
1984
Demonstration of a free elastolytic metalloenzyme in human lung lavage fluid and its relationship to alpha 1-antiprotease.
Although the human alveolar macrophage in tissue culture can secrete an elastolytic metalloenzyme that is not inactivated by… 
Highly Cited
1978
Highly Cited
1978
Degradation of cartilage proteoglycans by a neutral proteinase secreted by rabbit bone-marrow macrophages in culture.
When cultivated together with pieces of cartilage biosynthetically labelled with 35S in their proteoglycans, rabbit macrophages…