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Metalloproteases

Known as: Metallopeptidase, Metalloproteinases, METALLOPROTEASE 
A proteolytic enzyme that uses a metal ion, usually zinc, to catalyze the hydrolysis of peptide bonds. This protease is inhibited by metal chelating… 
National Institutes of Health

Related topics

Related topics

40 relations

Narrower (22)

ADAMTSAMMP protein, Armillaria melleaAstl protein, mouseBJ-PI2 non-hemorrhagic metalloproteinase, Bothrops jararaca

Broader (1)

Endopeptidases
Enzyme GeneHydrolysisIn BloodLMLN gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2003
Highly Cited
2003
Uniaxial strain upregulates matrix-degrading enzymes produced by human vascular smooth muscle cells.
Arteries remodel in response to environmental changes. We investigated whether mechanical strain modulates production of matrix… 
Review
2000
Review
2000
Interactions between tumour cells and stromal cells and proteolytic modification of the extracellular matrix by metalloproteinases in cancer.
Highly Cited
1995
Highly Cited
1995
Cell-mediated Catabolism of Aggrecan
A rat chondrosarcoma cell line and primary bovine chondrocytes have been used to study cell-mediated aggrecan catabolism… 
Highly Cited
1995
Highly Cited
1995
Proteinase expression in early mouse embryos is regulated by leukaemia inhibitory factor and epidermal growth factor.
Several proteinases from different multigene families have been implicated in the uterine invasion required for establishment of… 
Highly Cited
1994
Highly Cited
1994
Interstitial collagenase is required for angiogenesis in vitro.
Human umbilical vein endothelial cells (HUVECs) invade collagen gels and establish vascular-like structures within the gel… 
Review
1992
Review
1992
Cytokines and proteases in invasive processes: molecular similarities between inflammation and cancer.
Highly Cited
1990
Highly Cited
1990
cDNA cloning and expression of a metalloproteinase inhibitor related to tissue inhibitor of metalloproteinases.
The purification and characterization of a metalloproteinase inhibitor (MI) from bovine aortic endothelial cells, and the… 
Highly Cited
1990
Highly Cited
1990
Rapid one-step sandwich enzyme immunoassay for tissue inhibitor of metalloproteinases. An application for rheumatoid arthritis serum and plasma.
Highly Cited
1989
Highly Cited
1989
Characterization of gelatinase from pig polymorphonuclear leucocytes. A metalloproteinase resembling tumour type IV collagenase.
The metalloproteinase 'gelatinase' stored in the granules of pig polymorphonuclear leucocytes has been purified in the latent… 
Highly Cited
1981
Highly Cited
1981
An inhibitor of collagenase from human amniotic fluid. Purification, characterization and action on metalloproteinases.
1. An inhibitor of collagenase of apparent mol.wt. 28000 was isolated from term human amniotic fluid. 2. It is active against… 
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