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Extracellular proteolysis mediates tissue homeostasis. In cancer, altered proteolysis leads to unregulated tumor growth, tissue… Expand Interleukin 17 (IL-17) has been linked to autoimmune diseases, although its regulation and function have remained unclear. Here… Expand Severe acute respiratory syndrome (SARS) is an acute infectious disease that spreads mainly via the respiratory route. A distinct… Expand Abstract— Matrix metalloproteinases (MMPs), also designated matrixins, hydrolyze components of the extracellular matrix. These… Expand Spike (S) proteins of coronaviruses, including the coronavirus that causes severe acute respiratory syndrome (SARS), associate… Expand Matrix metalloproteinases (MMPs) have long been associated with cancer-cell invasion and metastasis. This provided the rationale… Expand The matrix metalloproteinases (MMPs) constitute a multigene family of over 25 secreted and cell surface enzymes that process or… Expand A scheme based on the zinc binding site [1992, FEBS Lett. 312, 110–114] has been extended to classify zinc metalloproteases into… Expand Matrix metalloproteinases (MMPs) are a family of nine or more highly homologous Zn(++)-endopeptidases that collectively cleave… Expand Matrix metalloproteinases are an important group of zinc enzymes responsible for degradation of the extracellular matrix… Expand