• Publications
  • Influence
A rapid in vitro assay for quantitating the invasive potential of tumor cells.
The results suggest that this in vitro test allows the rapid and quantitative assessment of invasiveness and a means to screen for drugs which alter the invasive phenotype of tumor cells.
Basement membrane complexes with biological activity.
Molecular sieve studies on the soluble extract demonstrate that laminin, entactin, and nidogen are associated in large but dissociable complexes which may be a necessary intermediate in the deposition of basement membrane.
Association of increased basement membrane invasiveness with absence of estrogen receptor and expression of vimentin in human breast cancer cell lines
Data from these cell lines suggest that human breast cancer progression results first in the loss of ER, and subsequently in VIM acquisition, the latter being associated with increased metastatic potential through enhanced invasiveness.
A simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin, and fibroblast growth factor.
A tissue inhibitor of metalloproteinases that also inhibits collagenases was found to be a potent inhibitor of fibroblast growth factor-induced angiogenesis, allowing the ready quantitative assessment of angiogenic and anti-angiogenic factors.
Isolation and characterization of type IV procollagen, laminin, and heparan sulfate proteoglycan from the EHS sarcoma.
It is indicated that lysine-derived cross-links and disulfide bonds stabilize the collagenous component in the matrix but not the laminin or the heparan sulfate proteoglycan.
Laminin and other basement membrane components.
This paper presents a meta-modelling framework for designing modular models of BASEMENT MEMBRANE STRUCTURE and some of the models developed so far have shown high levels of similarity to conventional models.
A simplified laminin nomenclature.
Laminin--a glycoprotein from basement membranes.
Investigation of a large noncollagenous glycoprotein isolated from a mouse tumor that produces basement membrane shows that it is produced by a variety of cultured cells, suggesting that this protein or an immunologically related protein is a constituent of the basement membranes of these tissues.