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Matrix metalloproteinases: a review.
TLDR
The present review discusses in detail the primary structures and the overlapping yet distinct substrate specificities of MMPs as well as the mode of activation of the unique MMP precursors. Expand
MT1-MMP-Deficient Mice Develop Dwarfism, Osteopenia, Arthritis, and Connective Tissue Disease due to Inadequate Collagen Turnover
TLDR
The findings demonstrate the pivotal function of MT1-MMP in connective tissue metabolism, and illustrate that modeling of the soft connective tissues matrix by resident cells is essential for the development and maintenance of the hard tissues of the skeleton. Expand
Proteolytic remodeling of extracellular matrix.
TLDR
Evidence is emerging that these enzymes also play an important regulatory role in matrix remodeling by catalyzing the processing of inactive matrix metalloproteinase and cytokine precursors. Expand
The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family.
TLDR
Observations support the view that the cysteine-switch mechanism is applicable to all members of this gene family and offers the opportunity for multiple modes of physiological activation of these important enzymes. Expand
Tumor cell traffic through the extracellular matrix is controlled by the membrane-anchored collagenase MT1-MMP
TLDR
It is found that fibroblasts and cancer cells express an indistinguishable pericellular collagenolytic activity that allows them to traverse the ECM and that MT1-MMP serves as the major cell-associated proteinase necessary to confer normal or neoplastic cells with invasive activity. Expand
MT1-MMP–dependent neovessel formation within the confines of the three-dimensional extracellular matrix
TLDR
The membrane-anchored MMP, MT1-MMP, confers endothelial cells with the ability to express invasive and tubulogenic activity in a collagen-rich milieu, in vitro or in vivo, where it plays an indispensable role in driving neovessel formation. Expand
Role of matrix metalloproteinases in human periodontal diseases.
TLDR
A body of evidence suggests that bone resorption is initiated by removal of the osteoid layer by osteoblasts by means of a collagenase-dependent process, and MMP are involved in tissue destruction in human periodontal diseases is still indirect and circumstantial. Expand
Role of Matrix Metalloproteinases in Human Periodontal Diseases.
TLDR
A body of evidence suggests that bone resorption is initiated by removal of the osteoid layer by osteoblasts by means of a collagenase-dependent process, and evidence that MMP are involved in tissue destruction in human periodontal diseases is still indirect and circumstantial. Expand
Role of cytokines and inflammatory mediators in tissue destruction.
TLDR
Although the mere presence of enzymes and cytokines does not necessarily impart function per se, these observations suggest that some level of spatial or temporal linkage exists between metalloproteinase/cytokine expression and gingival inflammation. Expand
Multiple modes of activation of latent human fibroblast collagenase: evidence for the role of a Cys73 active-site zinc complex in latency and a "cysteine switch" mechanism for activation.
TLDR
All modes of activation of latent HFC are believed to involve the dissociation of Cys73 from the active-site zinc atom and its replacement by water, with the concomitant exposure of the active site. Expand
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