FAQ

ADAM15 protein, human

Known as: Disintegrin and Metalloproteinase Domain-Containing Protein 15, MDC-15, Metalloprotease RGD Disintegrin Protein 
Disintegrin and metalloproteinase domain-containing protein 15 (863 aa, ~93 kDa) is encoded by the human ADAM15 gene. This protein is involved in… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1996-2018
051019962018

Related topics

Related topics

16 relations

Broader (2)

ADAM ProteinsMembrane Proteins
ADAM15 geneCell AdhesionDisintegrin DomainEnzyme Gene
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Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
ADAM15 protein, human
Plasma membrane
Hydrolysis
Cell Adhesion
Membrane Proteins
Proteolysis

Papers overview

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Highly Cited
2008
Highly Cited
2008
The ectodomain shedding of E-cadherin by ADAM15 supports ErbB receptor activation.
The zinc-dependent disintegrin metalloproteinases (a disintegrin and metalloproteinases (ADAMs) have been implicated in several… (More)
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2006
2006
ADAM15 disintegrin is associated with aggressive prostate and breast cancer disease.
The aim of the current study was to evaluate the expression of ADAM15 disintegrin (ADAM15) in a broad spectrum of human tumors… (More)
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Highly Cited
2005
Highly Cited
2005
The disintegrin-metalloproteinases ADAM9, ADAM12, and ADAM15 are upregulated in gastric cancer.
The ADAMs (A disintegrin and metalloproteinase) are a family of cell-surface membrane glycoproteins, whose multidomain structure… (More)
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2004
2004
Expression of ADAM15 in lung carcinomas
ADAM15, a member of the ADAM (a disintegrin and metalloprotease) family, is a membrane protein containing both protease and… (More)
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Highly Cited
2003
Highly Cited
2003
Potential role for ADAM15 in pathological neovascularization in mice.
ADAM15 (named for a disintegrin and metalloprotease 15, metargidin) is a membrane-anchored glycoprotein that has been implicated… (More)
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Highly Cited
2003
Highly Cited
2003
Catalytic activity of ADAM8, ADAM15, and MDC-L (ADAM28) on synthetic peptide substrates and in ectodomain cleavage of CD23.
The ADAM family of disintegrin metalloproteases plays important roles in "ectodomain shedding," the process by which biologically… (More)
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2002
2002
Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases.
The adamalysins (ADAMs) are transmembrane glycoproteins involved in cell adhesion and proteolytic ectodomain processing of… (More)
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Highly Cited
1999
Highly Cited
1999
Cysteine-rich domain of human ADAM 12 (meltrin alpha) supports tumor cell adhesion.
The ADAMs (A disintegrin and metalloprotease) comprise a family of membrane-anchored cell surface proteins with a putative role… (More)
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Highly Cited
1998
Highly Cited
1998
Specific interaction of the recombinant disintegrin-like domain of MDC-15 (metargidin, ADAM-15) with integrin alphavbeta3.
MDC-15 (ADAM-15, metargidin), a membrane-anchored metalloprotease/disintegrin/cysteine-rich protein, is expressed on the surface… (More)
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1996
1996
Metargidin, a membrane-anchored metalloprotease-disintegrin protein with an RGD integrin binding sequence.
Cellular disintegrins are a family of membrane-anchored proteins with structural homology to snake venom metalloproteases and… (More)
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