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Structure of the 70S Ribosome Complexed with mRNA and tRNA
The crystal structure of the bacterial 70S ribosome refined to 2.8 angstrom resolution reveals atomic details of its interactions with messenger RNA (mRNA) and transfer RNA (t RNA) and metal ions also stabilize the intersubunit interface.
Structure of the 30S ribosomal subunit
The crystal structure of the 30S subunit from Thermus thermophilus, refined to 3 Å resolution, is reported, which will facilitate the interpretation in molecular terms of lower resolution structural data on several functional states of the ribosome from electron microscopy and crystallography.
Recognition of Cognate Transfer RNA by the 30S Ribosomal Subunit
- J. M. Ogle, D. Brodersen, W. M. Clemons, M. Tarry, A. Carter, V. Ramakrishnan
- Biology, ChemistryScience
- 4 May 2001
Crystal structures of the 30S ribosomal subunit in complex with messenger RNA and cognate transfer RNA in the A site, both in the presence and absence of the antibiotic paromomycin, have been solved…
Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics
- A. Carter, W. M. Clemons, D. Brodersen, R. Morgan-Warren, B. Wimberly, V. Ramakrishnan
- 21 September 2000
The functional implications of the high-resolution 30S crystal structure are described, and details of the interactions between the 30S subunit and its tRNA and mRNA ligands are inferred, which lead to a model for the role of the universally conserved 16S RNA residues A1492 and A1493 in the decoding process.
The Structure of the Ribosome with Elongation Factor G Trapped in the Posttranslocational State
- Yonggui Gao, M. Selmer, C. Dunham, A. Weixlbaumer, A. Kelley, V. Ramakrishnan
- Biology, ChemistryScience
- 30 October 2009
A crystal structure refined to 3.6 angstrom resolution of the ribosome trapped with EF-G in the posttranslocational state using the antibiotic fusidic acid is reported, providing insights into translocation and decoding.
The Crystal Structure of the Ribosome Bound to EF-Tu and Aminoacyl-tRNA
Crystal structures of the ribosome bound to elongation factors provide insights into translocation and decoding, and a series of conformational changes in EF-Tu and aminoacyl-tRNA suggests a communication pathway between the decoding center and the guanosine triphosphatase center of EF- Tu.
Crystal structure of an initiation factor bound to the 30S ribosomal subunit.
The crystal structure of a complex of IF1 and the 30S ribosomal subunit is reported, explaining how localized changes at the ribosome A site lead to global alterations in the conformation of the30S subunit.
Selection of tRNA by the Ribosome Requires a Transition from an Open to a Closed Form
The Mechanism for Activation of GTP Hydrolysis on the Ribosome
The crystal structure of EF-Tu and aminoacyl-tRNA bound to the ribosome with a GTP analog, to 3.2 angstrom resolution, suggests a universal mechanism for GTPase activation and hydrolysis in translational GTPases on the Ribosome.
The Structural Basis for the Action of the Antibiotics Tetracycline, Pactamycin, and Hygromycin B on the 30S Ribosomal Subunit