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Prospective identification of tumorigenic breast cancer cells
TLDR
The ability to prospectively identify tumorigenic cancer cells will facilitate the elucidation of pathways that regulate their growth and survival and strategies designed to target this population may lead to more effective therapies.
Stem cells, cancer, and cancer stem cells
Stem cell biology has come of age. Unequivocal proof that stem cells exist in the haematopoietic system has given way to the prospective isolation of several tissue-specific stem and progenitor
In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells.
TLDR
It is demonstrated that nonadherent mammospheres are enriched in early progenitor/stem cells and able to differentiate along all three mammary epithelial lineages and to clonally generate complex functional structures in reconstituted 3D culture systems.
Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma
TLDR
Data demonstrate that cells within the CD44+ population of human HNSCC possess the unique properties of cancer stem cells in functional assays for cancer stem cell self-renewal and differentiation and form unique histological microdomains that may aid in cancer diagnosis.
Phenotypic characterization of human colorectal cancer stem cells
TLDR
The results validate the stem cell working model in human CRC and provide a highly robust surface marker profile for CRC stem cell isolation.
Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells.
A workshop was convened by the AACR to discuss the rapidly emerging cancer stem cell model for tumor development and progression. The meeting participants were charged with evaluating data suggesting
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
TLDR
The results indicate that Bmi-1 is essential for the generation of self-renewing adult HSCs, which are required for haematopoiesis to persist for the lifetime of the animal.
Association of reactive oxygen species levels and radioresistance in cancer stem cells
TLDR
It is shown that normal mammary epithelial stem cells contain lower concentrations of ROS than their more mature progeny cells, and subsets of CSCs in some tumours contain lower ROS levels and enhanced ROS defences compared to their non-tumorigenic progeny, which may contribute to tumour radioresistance.
Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation
TLDR
It is shown that Bmi-1 is required for the self-renewal of stem cells in the peripheral and central nervous systems but not for their survival or differentiation but restricted neural progenitors from the gut and forebrain proliferate normally in the absence of B mi-1.
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