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halofuginone

Known as: 7-bromo-6-chlorofebrifugine, halofunginone, trans-(+/-)-7-Bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4(3H)-quinazolinone 
An orally-active quinazolinone alkaloid with potential antineoplastic activity. Halofuginone interferes with the signaling pathway of transforming… 
National Institutes of Health

Related topics

Related topics

15 relations
Angiogenesis InhibitionMatrix Metalloproteinase 2Metastasis SuppressionNCIt Antineoplastic Agent Terminology

Broader (6)

Angiogenesis InhibitorsAntineoplastic AgentsCoccidiostatsPiperidines

Narrower (1)

Stenorol

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Determination of fifteen coccidiostats in feed at carry-over levels using liquid chromatography-mass spectrometry.
2012
2012
Structure-activity relationship of nonacidic quinazolinone inhibitors of human microsomal prostaglandin synthase 1 (mPGES 1).
Microsomal prostaglandin E synthase 1 (mPGES-1) is a key enzyme of the arachidonic acid cascade. Its product PGE(2) plays an… 
2012
2012
Development and validation of a liquid chromatographic-tandem mass spectrometric method for determination of eleven coccidiostats in milk.
2010
2010
Discovery of 4,4-Disubstituted Quinazolin-2-ones as T-Type Calcium Channel Antagonists.
A novel series of quinazolinone T-type calcium channel antagonists have been prepared and evaluated using in vitro and in vivo… 
Highly Cited
2007
Highly Cited
2007
Inhibition of fibroblast to myofibroblast transition by halofuginone contributes to the chemotherapy-mediated antitumoral effect
Stromal myofibroblasts play an important role in tumor progression. The transition of fibroblasts to myofibroblasts is… 
2002
2002
Halofuginone inhibition of COL1A2 promoter activity via a c-Jun-dependent mechanism.
OBJECTIVE The naturally occurring compound halofuginone has been shown to antagonize collagen synthesis by fibroblasts both in… 
Highly Cited
1996
Highly Cited
1996
Inhibition of collagen synthesis and changes in skin morphology in murine graft-versus-host disease and tight skin mice: effect of halofuginone.
The effect of halofuginone, a plant alkaloid known to inhibit collagen type I synthesis, on skin collagen content and skin… 
1992
1992
Synthesis and X-ray crystallographic analysis of quinazolinone cholecystokinin/gastrin receptor ligands.
Compounds exemplified by 2-[2-(5-bromo-1H-indol-3-yl)ethyl]-3-[3-(1- methylethoxy)phenyl]-4(3H)-quinazolinone (3, IC50 = 0.0093… 
1981
1981
Antihypertensive pyrrolo[1,2-c]quinazolines and pyrrolo[1,2-c]quinazolinones.
The synthesis of a variety of pyrrolo[1,2-c]quinazolines and pyrrolo[1,2-c]quinazolinones is described. Several of these… 
Highly Cited
1979
Highly Cited
1979
Chemotherapy of bovine theileriosis with Halofuginone. Short communication.
Theileriosis is a haemoprotozoal infection caused by members of the genus Theileria. The most important species in cattle are T… 
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