halofuginone

Known as: 7-bromo-6-chlorofebrifugine, halofunginone, trans-(+/-)-7-Bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4(3H)-quinazolinone 
An orally-active quinazolinone alkaloid with potential antineoplastic activity. Halofuginone interferes with the signaling pathway of transforming… (More)
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Febrifugine, the bioactive constituent of one of the 50 fundamental herbs of traditional Chinese medicine, has been characterized… (More)
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Highly Cited
2009
Highly Cited
2009
A central challenge for improving autoimmune therapy is preventing inflammatory pathology without inducing generalized… (More)
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Highly Cited
2008
Highly Cited
2008
Fibrosis is a known feature of dystrophic muscles, particularly the diaphragm, in the mdx mouse. In this study we evaluated the… (More)
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Highly Cited
2004
Highly Cited
2004
Radiation-induced fibrosis is an untoward effect of high dose therapeutic and inadvertent exposure to ionizing radiation… (More)
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Review
2004
Review
2004
Transforming growth factor-beta (TGF-beta) plays a central role in fibrosis, contributing to the influx and activation of… (More)
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2000
2000
We have previously demonstrated that halofuginone, a low molecular weight quinazolinone alkaloid, is a potent inhibitor of… (More)
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Review
1998
Review
1998
1. Fibrosis is characterized by extracellular matrix deposition, of which collagen type I is the major constituent. The… (More)
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1997
1997
Proliferation of vascular smooth muscle cells (SMCs) and accumulation of extracellular matrix (ECM) components within the… (More)
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1993
1993
The effect of halofuginone--a plant alkaloid used as a coccidiostat in birds--on collagen metabolism was studied in various avian… (More)
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1991
1991
The efficacy of halofuginone lactate against natural Cryptosporidium parvum infection in 150 neonatal market calves of a mixed… (More)
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