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Matrix Metalloproteinase 2

Known as: 72kDa Gelatinase, Matrix Metalloproteinase-2, 72-kDa Type IV Collagenase 
72 kDa type IV collagenase (660 aa, ~74 kDa) is encoded by the human MMP2 gene. This protein is involved in both proteolysis and angiogenesis.
National Institutes of Health

Related topics

Related topics

24 relations
Angiogenic ProcessBMS-275291COLLAGENASEEnzyme Gene

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Col-1 peptide, human

Papers overview

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Highly Cited
2012
Highly Cited
2012
Prognostic significance of matrix metalloproteinase-2, -8, -9, and -13 in oral tongue cancer.
BACKGROUND Oral tongue squamous cell carcinoma (OTSCC) often metastasizes to cervical lymph nodes. Mechanisms of this disease… 
Highly Cited
2001
Highly Cited
2001
Development and in vitro efficacy of novel MMP2 and MMP9 specific doxorubicin albumin conjugates.
Highly Cited
2000
Highly Cited
2000
Expression of matrix metalloproteinase-2 and -9 and their inhibitors in peripheral blood cells of patients with chronic hepatitis C.
BACKGROUND To clarify whether circulating matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) can be used as… 
Highly Cited
1997
Highly Cited
1997
Tumor cell invasion through matrigel is regulated by activated matrix metalloproteinase-2.
We tested the hypothesis that there is a correlation between tumor cell efficiency in activation of matrix metalloproteinase-2… 
1996
1996
Matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 expression and synthetic matrix metalloproteinase-2 inhibitor binding in ovarian carcinomas and tumor cell lines.
Enhanced matrix metalloproteinase-2 (MMP-2/72-kd type IV collagenase) action correlates with invasion in neoplasia. MMP-2 is… 
Highly Cited
1993
Highly Cited
1993
Defining the critical gene expression changes associated with expression and suppression of the tumorigenic and metastatic phenotype in Ha-ras-transformed cloned rat embryo fibroblast cells.
Carcinogenesis requires a complex series of genetic changes often involving multiple oncogenes and the inactivation of multiple… 
Highly Cited
1993
Highly Cited
1993
Cleavage and activation of corneal matrix metalloproteases by Pseudomonas aeruginosa proteases.
PURPOSE To examine the effect of Pseudomonas aeruginosa on the expression of corneal matrix metalloproteases and the effect of… 
Highly Cited
1992
Highly Cited
1992
Production of both 92- and 72-kDa gelatinases by bone cells.
Highly Cited
1991
Highly Cited
1991
Binding of tissue inhibitor of metalloproteinases 2 to two distinct sites on human 72-kDa gelatinase. Identification of a stabilization site.
Highly Cited
1991
Highly Cited
1991
Purification and characterization of human 72-kDa gelatinase (type IV collagenase). Use of immunolocalisation to demonstrate the non-coordinate regulation of the 72-kDa and 95-kDa gelatinases by…
Human gingival fibroblast gelatinase (type IV collagenase) has been purified to homogeneity using a combination of ion exchange… 
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