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The IIIc alternative of Fgfr2 is a positive regulator of bone formation.
TLDR
Results suggest that Fgfr2IIIc, the mesenchymal splice variant of FGFR2, is a positive regulator of ossification affecting mainly the osteoblast, but also the chondrocyte, lineages. Expand
Prevention of liver cirrhosis in rats by curcumin
TLDR
The aim of the present study was to examine the efficacy of curcumin in preventing thioacetamide‐induced cirrhosis and to unravel the mechanism ofCurcumin's effect on hepatic fibrosis in rats. Expand
Halofuginone to treat fibrosis in chronic graft-versus-host disease and scleroderma.
TLDR
The results of the human studies provide basis for using halofuginone treatment for dermal fibrosis and as a first step toward future treatment of internal organ involvement, an oral administration study was performed in which halofUGinone was well tolerated and plasma levels surpassed the predicted therapeutic exposure. Expand
Prevention of muscle fibrosis and improvement in muscle performance in the mdx mouse by halofuginone
TLDR
It is suggested that via its effect on Smad3 phosphorylation, halofuginone inhibits muscle fibrosis and improves cardiac and skeletal muscle functions in mdx mice. Expand
Functional resolution of fibrosis in mdx mouse dystrophic heart and skeletal muscle by halofuginone.
TLDR
Marked improvements in vital-organ functions implicate Halo as a strong candidate drug to reduce morbidity and mortality in Duchenne muscular dystrophy. Expand
A common pathway mediated through Toll-like receptors leads to T- and natural killer-cell immunosuppression.
TLDR
It is demonstrated that Toll-like receptors play a major role in the induction of innate and adaptive immune system suppression; repetitive administration of single TLR 2, 3, 4, or 9 agonists was sufficient to induce a bystander NK- and T-cell immunosuppression associated with zeta-chain down-regulation mediated by myeloid suppressor cells. Expand
Gene expression and tibial dyschondroplasia.
TLDR
A hypothesis for the sequence of events responsible for the development of tibial dyschondroplastic lesions is described and naturally occurring or induced genetic mutations in other species can provide important clues to possible mechanisms responsible for lesion development. Expand
The effect of inhibition of heat-shock proteins on thiram-induced tibial dyschondroplasia.
TLDR
In contrast to the anti-angiogenic effect of 17-DMAG observed in mammals, inhibition of Hsp90 activity in the unvascularized TD-affected growth plates resulted in activation of the angiogenic switch and restored normal growth-plate morphology. Expand
The amino acid requirements of growing turkeys. 1. Model construction and parameter estimation.
TLDR
Protein and amino acid analyses of nude carcass and feathers and the growth curve were used to calculate the requirements for growth and energy intake predicted by equations included previously determined coefficients for maintenance and growth. Expand
Halofuginone: a potent inhibitor of critical steps in angiogenesis progression
TLDR
The ability of halofuginone to interfere with key events in neovascularization, together with its oral bioavailability and safe use as an anti‐parasitic agent, make it a promis¬ing drug for further evaluation in the treatment of a wide range of diseases associated with pathological angiogenesis. Expand
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