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Improved stability of Drosophila larval neuromuscular preparations in haemolymph-like physiological solutions
- B. Stewart, H. Atwood, J. Renger, J. Wang, CF Wu
- BiologyJournal of Comparative Physiology
- 1 August 1994
Haemolymph-like solutions allow for prolonged, stable recording of synaptic transmission, and Voltage-clamp experiments suggest that these effects are linked to more pronounced activation of muscle fiber membrane conductances in standard solutions, rather than to differences in passive muscle membrane properties or changes in postsynaptic receptor channel kinetics.
Selective T-Type Calcium Channel Block in Thalamic Neurons Reveals Channel Redundancy and Physiological Impact of ITwindow
Using TTA-P2, the first direct demonstration of the presence of a window component of Ca2+ channels in neurons and its contribution to the resting membrane potential of thalamic neurons and to the Up state of their intrinsically generated slow (<1 Hz) oscillation is provided.
A Developmental Switch in Neurotransmitter Flux Enhances Synaptic Efficacy by Affecting AMPA Receptor Activation
International Union of Basic and Clinical Pharmacology. LXXXVI. Orexin Receptor Function, Nomenclature and Pharmacology
- A. Gotter, A. Webber, P. Coleman, J. Renger, C. Winrow
- Biology, PsychologyPharmacological Reviews
- 1 July 2012
Combined genetic and pharmacological approaches indicate that orexin signaling may represent a confluence of sleep, feeding, and reward pathways and selective oX2 receptor antagonism takes advantage of these properties toward the development of novel insomnia therapeutics.
Calcineurin Signaling Mediates Activity-Dependent Relocation of the Axon Initial Segment
Calcineurin is emphasized as a vital player in the regulation of intrinsic plasticity as governed by the AIS because neither membrane resistance changes nor spine density changes were affected by FK506 treatment, suggesting that calcineur in acts via a separate pathway to modulate AIS plasticity.
Essential Thalamic Contribution to Slow Waves of Natural Sleep
It is demonstrated that the thalamus finely tunes the frequency of slow waves during non-REM sleep and anesthesia, and thus provides the first conclusive evidence that a dynamic interplay of the neocortical and thalamic oscillators ofSlow waves is required for the full expression of this key physiological EEG rhythm.
Presynaptic HCN1 channels regulate CaV3.2 activity and neurotransmission at select cortical synapses
It is found that HCN1 subunits are also localized to the active zone of mature asymmetric synaptic terminals targeting mouse entorhinal cortical layer III pyramidal neurons, which represents a previously unknown mechanism by which HCN channels regulate synaptic strength and thereby neural information processing and network excitability.
Design, synthesis, and evaluation of a novel 4-aminomethyl-4-fluoropiperidine as a T-type Ca2+ channel antagonist.
Structural modification of the p Piperidine leads 1 and 2 afforded the fluorinated piperidine ( S)- 5, a potent and selective antagonist that displayed in vivo CNS efficacy without adverse cardiovascular effects.
Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors
The orexin (also known as hypocretin) G protein–coupled receptors (GPCRs) regulate sleep and other behavioral functions in mammals, and are therapeutic targets for sleep and wake disorders. The human…
In Vitro Characterization of T-Type Calcium Channel Antagonist TTA-A2 and In Vivo Effects on Arousal in Mice
The discovery of the potent and selective T-type channel antagonist TTA-A2 has enabled us to study the in vivo effects of pharmacological T-channel inhibition on arousal in mice, and it will help to explore the validity of these channels as potential drug targets for sleep-related and other neurological diseases.