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glutamate decarboxylation to succinate
Known as:
degradation of glutamate to succinate through GABA
, glutamate degradation via 4-aminobutyrate
, gamma-aminobutyrate shunt
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The chemical reactions and pathways resulting in the formation of succinate from glutamate. Also known as GABA (gamma-aminobutyrate) shunt since it…
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National Institutes of Health
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Related topics
Related topics
2 relations
Narrower (2)
4-aminobutyrate aminotransferase activity
glutamate decarboxylase activity
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
Elimination of KATP Channels in Mouse Islets Results in Elevated [U-13C]Glucose Metabolism, Glutaminolysis, and Pyruvate Cycling but a Decreased γ-Aminobutyric Acid Shunt*
Changhong Li
,
I. Nissim
,
+8 authors
F. Matschinsky
Journal of Biological Chemistry
2008
Corpus ID: 31841212
Pancreatic beta cells are hyper-responsive to amino acids but have decreased glucose sensitivity after deletion of the…
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2006
2006
Inhibition of GABA shunt enzymes' activity by 4-hydroxybenzaldehyde derivatives.
Y. Tao
,
Zheng Yuan
,
Xiao-qiao Tang
,
Hui-bi Xu
,
X. Yang
Bioorganic & Medicinal Chemistry Letters
2006
Corpus ID: 41924243
Highly Cited
2003
Highly Cited
2003
Vigabatrin, but not Gabapentin or Topiramate, Produces Concentration‐related Effects on Enzymes and Intermediates of the GABA Shunt in Rat Brain and Retina
G. Sills
,
E. Butler
,
G. Forrest
,
N. Ratnaraj
,
P. Patsalos
,
M. Brodie
Epilepsia
2003
Corpus ID: 8239930
Summary: Purpose: The antiepileptic drug (AED) vigabatrin (VGB), which exerts its pharmacologic effects on the γ‐aminobutyric…
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2003
2003
The altered expression of GABA shunt enzymes in the gerbil hippocampus before and after seizure generation
T. Kang
,
Seung-Kook Park
,
+6 authors
M. Won
Neurochemistry International
2003
Corpus ID: 38139317
2001
2001
The alteration of γ-aminobutyric acid-transaminase expression in the gerbil hippocampus induced by seizure
T. Kang
,
Seung-Kook Park
,
+5 authors
M. Won
Neurochemistry International
2001
Corpus ID: 19598080
2000
2000
Plant succinic semialdehyde dehydrogenase: dissection of nucleotide binding by surface plasmon resonance and fluorescence spectroscopy.
K. Busch
,
J. Piehler
,
H. Fromm
Biochemistry
2000
Corpus ID: 36743614
Recent kinetic studies revealed distinct modes of inhibition of mitochondrial Arabidopsis thaliana succinic semialdehyde…
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1993
1993
Isolation and characterization of recombinant mitochondrial 4-aminobutyrate aminotransferase.
J. Park
,
Y. Osei
,
J. Churchich
Journal of Biological Chemistry
1993
Corpus ID: 25378375
1990
1990
Effect of maternal iron deficiency on GABA shunt pathway of developing rat brain.
V. Taneja
,
K. Mishra
,
K. Agarwal
Indian journal of experimental biology
1990
Corpus ID: 34802341
Iron deficiency during pregnancy and lactation (35 mg iron/kg diet) produced a significant reduction in liver nonheme iron in…
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1986
1986
Effect of early iron deficiency in rat on the gamma-aminobutyric acid shunt in brain.
V. Taneja
,
K. Mishra
,
K. Agarwal
Journal of Neurochemistry
1986
Corpus ID: 44296111
Early iron deficiency in rat does not affect the weight or the protein, DNA, and RNA content but results in a slight reduction in…
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1983
1983
Cortical GABA Turnover During Bicuculline Seizures in Rats
A. Chapman
,
M. Evans
Journal of Neurochemistry
1983
Corpus ID: 1422463
Abstract: The rate of cortical γ‐aminobutyric acid (GABA) turnover was estimated by determining the rate of GABA accumulation…
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