glutamate decarboxylation to succinate

Known as: degradation of glutamate to succinate through GABA, glutamate degradation via 4-aminobutyrate, gamma-aminobutyrate shunt 
The chemical reactions and pathways resulting in the formation of succinate from glutamate. Also known as GABA (gamma-aminobutyrate) shunt since it… (More)
National Institutes of Health

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4-aminobutyrate aminotransferase activityglutamate decarboxylase activity

Papers overview

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Review
2015
Review
2015
Closing the loop on the GABA shunt in plants: are GABA metabolism and signaling entwined?
γ-Aminobutyric acid (GABA) is a non-proteinogenic amino acid that is found in uni- and multi-cellular organisms and is involved… (More)
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2014
2014
Succinate is an inflammatory signal that induces IL-1 beta through HIF-1 alpha
Macrophages activated by the gram negative bacterial product lipopolysaccharide (LPS) switch their core metabolism from oxidative… (More)
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Highly Cited
2014
Highly Cited
2014
Human breast cancer metastases to the brain display GABAergic properties in the neural niche.
Dispersion of tumors throughout the body is a neoplastic process responsible for the vast majority of deaths from cancer. Despite… (More)
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Highly Cited
2011
Highly Cited
2011
Dynamic metabonomic responses of tobacco (Nicotiana tabacum) plants to salt stress.
Metabolic responses are important for plant adaptation to osmotic stresses. To understand the dosage and duration dependence of… (More)
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2011
2011
Transcriptomic and proteomic analyses of the Aspergillus fumigatus hypoxia response using an oxygen-controlled fermenter
Aspergillus fumigatus is a mold responsible for the majority of cases of aspergillosis in humans. To survive in the human body, A… (More)
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2011
2011
Succinic semialdehyde dehydrogenase is involved in the robust patterning of Arabidopsis leaves along the adaxial-abaxial axis.
Polarity along the adaxial-abaxial axis of the leaf is essential for leaf development and morphogenesis. One of the genes that… (More)
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Highly Cited
2011
Highly Cited
2011
A mitochondrial GABA permease connects the GABA shunt and the TCA cycle, and is essential for normal carbon metabolism.
In plants, γ-aminobutyric acid (GABA) accumulates in the cytosol in response to a variety of stresses. GABA is transported into… (More)
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2008
2008
Contribution of the GABA shunt to hypoxia-induced alanine accumulation in roots of Arabidopsis thaliana.
When subjected to low oxygen stress, plants accumulate alanine and gamma-aminobutyric acid (GABA). To investigate the function of… (More)
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Highly Cited
2007
Highly Cited
2007
Reduced expression of succinyl-coenzyme A ligase can be compensated for by up-regulation of the gamma-aminobutyrate shunt in illuminated tomato leaves.
Increasing experimental evidence suggests that the tricarboxylic acid cycle in plants is of greater importance in illuminated… (More)
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Highly Cited
2003
Highly Cited
2003
Mitochondrial succinic-semialdehyde dehydrogenase of the gamma-aminobutyrate shunt is required to restrict levels of reactive oxygen intermediates in plants.
The gamma-aminobutyrate (GABA) shunt is a metabolic pathway that bypasses two steps of the tricarboxylic acid cycle, and it is… (More)
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