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Endothelial progenitor cell homing: prominent role of the IGF2-IGF2R-PLCbeta2 axis.
Homing of endothelial progenitor cells (EPCs) to the neovascular zone is now considered to be an essential step in the formation of vascular networks during embryonic development and also for… Expand
Antioxidant properties of extract and fractions from Enteromorpha prolifera, a type of green seaweed.
The ethanol extract and its solvent subfractions, partitioned by n-hexane (HX), chloroform (CF) and ethylacetate (EA), from Enteromorpha prolifera were measured for antioxidant activities, and a… Expand
Forskolin increases angiogenesis through the coordinated cross-talk of PKA-dependent VEGF expression and Epac-mediated PI3K/Akt/eNOS signaling.
Forskolin, a potent activator of adenylyl cyclases, has been implicated in modulating angiogenesis, but the underlying mechanism has not been clearly elucidated. We investigated the signal mechanism… Expand
Activation of microglia and induction of pro-inflammatory cytokines in the hippocampus of type 2 diabetic rats
Abstract Objectives: The majority of immune cells in the brain are comprised of microglia, which undergo morphological changes when activated to remove damaged neurons and infectious agents from the… Expand
Eugenol protects neuronal cells from excitotoxic and oxidative injury in primary cortical cultures
- M. Wie, M. Won, K. Lee, Joon-Hyun Shin, Yung-Hi Kim
- Biology, Medicine
- Neuroscience Letters
- 4 April 1997
We examined the neuroprotective efficacy of eugenol against N-methyl-D-aspartate (NMDA)-, oxygen-glucose deprivation-, and xanthine/xanthine oxidase-induced neurotoxicity in primary murine cortical… Expand
Melatonin improves d‐galactose‐induced aging effects on behavior, neurogenesis, and lipid peroxidation in the mouse dentate gyrus via increasing pCREB expression
Abstract: Melatonin (N‐acetyl‐5‐methoxytryptamine) has multiple functions. In this study, we investigated the effects of melatonin on memory, cell proliferation, and neuroblast differentiation in… Expand
Functional role of NF-κB in expression of human endothelial nitric oxide synthase.
- K. Lee, Joohwan Kim, +8 authors Y. Kim
- Chemistry, Medicine
- Biochemical and biophysical research…
- 23 May 2014
The transcription factor NF-κB has an essential role in inflammation in endothelial cells. Endothelial nitric oxide synthase (eNOS)-derived nitric oxide (NO) prevents vascular inflammation. However,… Expand
Zizyphus attenuates ischemic damage in the gerbil hippocampus via its antioxidant effect.
The fruit of Zizyphus jujuba has been used as a traditional Chinese medicinal herb and considered for thousands of years to affect various physiological functions in the body. We obtained a Z. jujuba… Expand
Reduced Cell Proliferation and Neuroblast Differentiation in the Dentate Gyrus of High Fat Diet-Fed Mice are Ameliorated by Metformin and Glimepiride Treatment
We investigated the effects of a high-fat diet (HFD) and the subsequent treatment of metformin (met) and glimepiride (glim), which are widely prescribed for type 2 diabetes, on cell proliferation and… Expand
Effects of melatonin on cognitive impairment and hippocampal neuronal damage in a rat model of chronic cerebral hypoperfusion
- C. H. Lee, J. Park, J. Ahn, M. Won
- Biology, Medicine
- Experimental and therapeutic medicine
- 1 April 2016
Chronic cerebral hypoperfusion (CCH), which induces oxidative stress and inflammation in the brain, has previously been associated with cognitive impairment and neuronal cell damage. Melatonin is a… Expand