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Structural Linkage between Ligand Discrimination and Receptor Activation by Type I Interferons
Helical Structures of ESCRT-III Are Disassembled by VPS4
It is found that the ESCRT-III proteins CHMP2A and CHMP3 (charged multivesicular body proteins 2A and 3) could assemble in vitro into helical tubular structures that could assemble within the neck of an inwardly budding vesicle, catalyzing late steps in budding under the control of VPS4.
Structural and dynamic determinants of type I interferon receptor assembly and their functional interpretation
A simple model is presented, which explains differential IFN activities based on rapid endocytosis of signaling complexes and negative feedback mechanisms interfering with ternary complex assembly, which will eventually lead to therapeutic applications of IFNs with increased efficacy.
Differential receptor subunit affinities of type I interferons govern differential signal activation.
The receptor of the type I interferon family.
- G. Uzé, G. Schreiber, J. Piehler, S. Pellegrini
- BiologyCurrent topics in microbiology and immunology
This review summarizes results from the last decade that contributed to the current state of knowledge of IFN-receptor complex structure and assembly.
New methodologies for measuring protein interactions in vivo and in vitro.
- J. Piehler
- BiologyCurrent opinion in structural biology
- 1 February 2005
Inquiring into the differential action of interferons (IFNs): an IFN-alpha2 mutant with enhanced affinity to IFNAR1 is functionally similar to IFN-beta.
It is shown that the differential activities of IFN-beta are directly related to the binding affinity for IFNAR1, and conservation of the residues mutated in the HEQ mutant within IFn-alpha subtypes suggests that IFN"-alpha has evolved to bind IFN AR1 weakly, apparently to sustain differential levels of biological activities compared to those induced by IFN -beta.
ISG15 deficiency and increased viral resistance in humans but not mice
Patients with ISG15-deficient patients who display no enhanced susceptibility to viruses in vivo are described, in stark contrast to Isg15- deficient mice.
Ultrathin nucleoporin phenylalanine–glycine repeat films and their interaction with nuclear transport receptors
Nuclear pore complexes (NPCs) are highly selective gates that mediate the exchange of all proteins and nucleic acids between the cytoplasm and the nucleus. Their selectivity relies on a…
USP18-Based Negative Feedback Control Is Induced by Type I and Type III Interferons and Specifically Inactivates Interferon α Response
It is shown that priming of cells with either type I IFN or type III IFN interferes with the cell's ability to further respond to all IFN α subtypes, and primed cells are differentially desensitized in that they retain sensitivity to IFN β.