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gemifloxacin

Known as: 7-(3-aminomethyl-4-methoxyimino-pyrrolidine-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-(1,8)-naphthyridine-3-carboxylic acid, gemifloxacin [Chemical/Ingredient] 
A fluoroquinolone antibiotic with antimicrobial property. Gemifloxacin enters bacterial cells by diffusion through integral membrane porin pathway… 
National Institutes of Health

Related topics

Related topics

20 relations

Broader (4)

Anti-Bacterial AgentsFluoroquinolonesNaphthyridinesTopoisomerase II Inhibitors
Bacterial InfectionsBronchitisCommunity-Acquired InfectionsDrug Allergy

Narrower (4)

FactiveLB 20304SB-265805gemifloxacin mesylate

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Synthesis and antibacterial activity of naphthyridone derivatives containing mono/difluoro-methyloxime pyrrolidine scaffolds.
Review
2003
Review
2003
Five-year analysis of Haemophilus influenzae isolates with reduced susceptibility to fluoroquinolones: prevalence results from the SENTRY antimicrobial surveillance program.
2003
2003
Topoisomerase Targeting with and Resistance to Gemifloxacin in Staphylococcus aureus
ABSTRACT Gemifloxacin, a novel quinolone with potent activity against Staphylococcus aureus, was 8- to 16-fold more active… 
2003
2003
Rickettsialpox in Turkey
To the Editor: Rickettsialpox is often described as a chickenpox-like disease and is caused by Rickettsia akari, a spotted fever… 
2002
2002
Chiral separation of gemifloxacin in sodium‐ containing media using chiral crown ether as a chiral selector by capillary and microchip electrophoresis
Chiral crown ether, (+)‐(18‐crown‐6)‐tetracarboxylic acid (18C6H4), is an effective chiral selector for resolving enantiomeric… 
2001
2001
Efficacy and safety of gemifloxacin in the treatment of community-acquired pneumonia: a randomized, double-blind comparison with trovafloxacin.
Sir, File et al. reported eradication rates for Mycoplasma pneumoniae of 93% for gemifloxacin and 95% for trovafloxacin, although… 
Highly Cited
2000
Highly Cited
2000
Potent Antipneumococcal Activity of Gemifloxacin Is Associated with Dual Targeting of Gyrase and Topoisomerase IV, an In Vivo Target Preference for Gyrase, and Enhanced Stabilization of Cleavable…
ABSTRACT We investigated the roles of DNA gyrase and topoisomerase IV in determining the susceptibility of Streptococcus… 
2000
2000
Comparative in vitro potency of gemifloxacin against European respiratory tract pathogens isolated in the Alexander Project.
European isolates collected in 1998 for the Alexander Project were tested for their susceptibility to ciprofloxacin, ofloxacin… 
Highly Cited
1999
Highly Cited
1999
The in-vitro activity and tentative breakpoint of gemifloxacin, a new fluoroquinolone.
The in-vitro activity of gemifloxacin, a new fluoroquinolone, against a wide range (c. 700) of recent clinical isolates, was… 
1999
1999
Activity of Gemifloxacin against Penicillin- and Ciprofloxacin-Resistant Streptococcus pneumoniae Displaying Topoisomerase- and Efflux-Mediated Resistance Mechanisms
ABSTRACT Nine penicillin-resistant Streptococcus pneumoniaeclinical isolates from Northern Ireland, resistant to ciprofloxacin… 
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