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gefitinib

Known as: 4-(3Chloro-4-flurophenylamine)-7-methoxy-6(3-(4morpholinyl)quinazoline, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholin) propoxy]-4-quinazolinamine, gefitinib [Chemical/Ingredient] 
An anilinoquinazoline with antineoplastic activity. Gefitinib inhibits the catalytic activity of numerous tyrosine kinases including the epidermal… Expand
National Institutes of Health

Papers overview

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Review
2019
Review
2019
Activating mutations of the epidermal growth factor receptor gene (EGFR) are a driving force for some lung adenocarcinomas… Expand
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Review
2018
Review
2018
The major current conventional types of metastatic breast cancer (MBC) treatments include surgery, radiation, hormonal therapy… Expand
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Highly Cited
2010
Highly Cited
2010
BACKGROUND Non-small-cell lung cancer with sensitive mutations of the epidermal growth factor receptor (EGFR) is highly… Expand
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Highly Cited
2009
Highly Cited
2009
BACKGROUND Previous, uncontrolled studies have suggested that first-line treatment with gefitinib would be efficacious in… Expand
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Highly Cited
2007
Highly Cited
2007
The epidermal growth factor receptor (EGFR) kinase inhibitors gefitinib and erlotinib are effective treatments for lung cancers… Expand
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Highly Cited
2005
Highly Cited
2005
Mutations of the epidermal growth factor receptor (EGFR) gene have been identified in specimens from patients with non-small-cell… Expand
Is this relevant?
Highly Cited
2005
Highly Cited
2005
Background Lung adenocarcinomas from patients who respond to the tyrosine kinase inhibitors gefitinib (Iressa) or erlotinib… Expand
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Gefitinib is a selective inhibitor of the epidermal growth factor (EGFR) tyrosine kinase, which is overexpressed in… Expand
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Receptor tyrosine kinase genes were sequenced in non–small cell lung cancer (NSCLC) and matched normal tissue. Somatic mutations… Expand
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Most patients with non-small-cell lung cancer have no response to the tyrosine kinase inhibitor gefitinib, which… Expand
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