ZD 1839

Known as: ZD1839 
 
National Institutes of Health

Papers overview

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Highly Cited
2004
Highly Cited
2004
PURPOSE The purpose of this study was to determine whether the addition of the epidermal growth factor receptor tyrosine kinase… (More)
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Highly Cited
2004
Highly Cited
2004
PURPOSE Preclinical studies indicate that gefitinib (Iressa, ZD1839; AstraZeneca, Wilmington, DE), an orally active epidermal… (More)
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Highly Cited
2003
Highly Cited
2003
The development of acquired resistance to antihormonal agents in breast cancer is a major therapeutic problem. We have developed… (More)
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Highly Cited
2003
Highly Cited
2003
PURPOSE To evaluate the efficacy and tolerability of two doses of gefitinib (Iressa [ZD1839]; AstraZeneca, Wilmington, DE), a… (More)
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Highly Cited
2002
Highly Cited
2002
PURPOSE To establish the safety and tolerability of ZD1839 (Iressa), a selective epidermal growth factor receptor (EGFR) tyrosine… (More)
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Highly Cited
2002
Highly Cited
2002
PURPOSE To investigate the tolerability, pharmacokinetics, and antitumor activity of the oral, selective epidermal growth factor… (More)
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Review
2002
Review
2002
The epidermal growth factor receptor (EGFR) is a rational target for antitumor strategies. EGFR signaling causes increased… (More)
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Highly Cited
2001
Highly Cited
2001
The epidermal growth factor receptor (EGFR) is commonly overexpressed in many human tumors and provides a new target for… (More)
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Highly Cited
2000
Highly Cited
2000
Transforming growth factor alpha (TGF-alpha) is an autocrine growth factor for human cancer. Overexpression of TGF-alpha and its… (More)
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Review
2000
Review
2000
Human carcinomas frequently express high levels of receptors in the EGF receptor family, and overexpression of at least two of… (More)
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