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fosinoprilat

Known as: L-Proline, 4-cyclohexyl-1-((hydroxy(4-phenylbutyl)phosphinyl)acetyl)-, trans-, SQ 27,519, fosinoprilic acid 
A phosphinic acid-containing angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Fosinoprilat specifically and… Expand
National Institutes of Health

Papers overview

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2000
2000
AIMS To compare the serum pharmacokinetics of fosinoprilat with enalaprilat and lisinopril after 1 and 10 days of dosing with… Expand
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Highly Cited
1998
Highly Cited
1998
Combined inhibition of neutral endopeptidase (NEP) and angiotensin converting enzyme (ACE) produces cardiovascular effects… Expand
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Highly Cited
1997
Highly Cited
1997
Angiotensin I-converting enzyme (ACE) is composed of two highly similar domains (referred to here as the N and C domains) that… Expand
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Highly Cited
1996
Highly Cited
1996
A soluble 67 kDa angiotensin-converting enzyme (ACE) has been purified by lisinopril-Sepharose affinity column chromatography… Expand
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Highly Cited
1991
Highly Cited
1991
The specific neutral endopeptidase (NEP) inhibitor, SQ 29,072 (7-{2-(mercaptomethyl)-1-oxo-3-phenylpropyl]amino}heptanoic acid… Expand
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Highly Cited
1991
Highly Cited
1991
We determined the relationship between cardiac angiotensin-converting enzyme (ACE) inhibition and anti-ischemic efficacy of… Expand
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Highly Cited
1991
Highly Cited
1991
Single‐dose kinetics of fosinopril, a new phosphorus‐containing angiotensin‐converting enzyme inhibitor and its active diacid… Expand
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1990
1990
The relative contribution of the gut, liver, and lung to the first-pass hydrolysis (bioactivation) of the orally administered… Expand
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1989
1989
Summary: Fosinopril is the first member of a new chemical class of angiotensin I (AI) converting enzyme (ACE) inhibitors, the… Expand
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Review
1989
Review
1989
There is increasing evidence that inhibition of tissue angiotensin converting enzyme (ACE) is important for the pharmacokinetics… Expand
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