• Publications
  • Influence
Shedding of somatic angiotensin-converting enzyme (ACE) is inefficient compared with testis ACE despite cleavage at identical stalk sites.
The somatic and testis isoforms of angiotensin-converting enzyme (ACE) are both C-terminally anchored ectoproteins that are shed by an unidentified secretase. Although testis and somatic ACE bothExpand
  • 75
  • 2
  • Open Access
Inhibition by converting enzyme inhibitors of pig kidney aminopeptidase P.
Several inhibitors of angiotensin converting enzyme were also found to inhibit aminopeptidase P, whereas inhibitors of other mammalian aminopeptidases were ineffective. Aminopeptidase P purified fromExpand
  • 62
  • 2
  • Open Access
Angiotensin-converting enzyme secretase is inhibited by zinc metalloprotease inhibitors and requires its substrate to be inserted in a lipid bilayer.
Mammalian angiotensin-converting enzyme (ACE; EC 3.4.15.1) is one of several proteins that exist in both membrane-bound and soluble forms as a result of a post-translational proteolytic processingExpand
  • 55
  • 1
  • Open Access
Obesity and Testosterone Levels in Ghanaian Men With Type 2 Diabetes
IN BRIEF Testosterone plays a vital role in obesity, glucose homeostasis, and lipid metabolism. The aim of this study was to investigate androgen levels and its association with obesity in GhanaianExpand
  • 9
  • 1
  • Open Access
Characterization of a secretase activity which releases angiotensin-converting enzyme from the membrane.
Angiotensin-converting enzyme (ACE; EC 3.4.1.15.1) exists in both membrane-bound and soluble forms. Phase separation in Triton X-114 and a competitive e.l.i.s.a. have been employed to characterizeExpand
  • 92
  • Open Access
Levels of Circulatory Endothelial Progenitor Cells and Gamma Glutamyltransferase in Ghanaians with Cardiovascular Disease
Endothelial progenitor cells (EPCs) play a key role in the vascular pathology of stroke, congestive cardiac failure (CCF) and hypertension. Reduced numbers of circulating endothelial progenitor cellsExpand
  • 1
Characterization of the soluble and membrane-bound forms of porcine angiotensin converting enzyme.
  • 2
Impact of exercise intensity on oxidative stress and selected metabolic markers in young adults in Ghana
ObjectiveThis study aimed to evaluate the effect of different levels of exercise on markers of oxidative stress and selected metabolic parameters in Ghanaian young adults.ResultsSignificant increasesExpand
  • 1
Characterization of the post-translational release from membranes of angiotensin converting enzyme.