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The Distribution and Mechanism of Action of Ghrelin in the CNS Demonstrates a Novel Hypothalamic Circuit Regulating Energy Homeostasis
TLDR
Using electrophysiological recordings, ghrelin stimulated the activity of arcuate NPY neurons and mimicked the effect of NPY in the paraventricular nucleus of the hypothalamus (PVH), thus representing a novel regulatory circuit controlling energy homeostasis. Expand
Diet-induced obesity causes severe but reversible leptin resistance in arcuate melanocortin neurons.
TLDR
By decreasing the fat content of the mouse's diet, leptin responsiveness of NPY/AgRP and POMC neurons recovered simultaneously, with mice regaining normal leptin sensitivity and glycemic control, and highlighting the physiological importance of leptin sensing in the melanocortin circuits. Expand
Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates.
TLDR
It is found that fetal offspring from both lean and obese mothers chronically consuming a HFD had a 3-fold increase in liver triglycerides (TGs), and exposure to this may increase the risk of pediatric NAFLD. Expand
The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss.
TLDR
These findings indicate that the GLP-1R on POMC/CART-expressing ARC neurons likely mediates liraglutide-induced weight loss. Expand
Developmental origins of disease and determinants of chromatin structure: maternal diet modifies the primate fetal epigenome.
TLDR
It is shown that a current significant in utero exposure (caloric-dense high-fat maternal diet) induces site-specific alterations in fetal hepatic H3 acetylation, and this results suggest that variations in the intrauterine environment in primates similarly induce changes in key determinants of hepatic chromatin structure. Expand
Chronic Consumption of a High-Fat Diet during Pregnancy Causes Perturbations in the Serotonergic System and Increased Anxiety-Like Behavior in Nonhuman Primate Offspring
TLDR
It is found that maternal high-fat diet (HFD) consumption during gestation caused perturbations in the central serotonergic system of fetal offspring, and female infants from HFD-fed mothers exhibited increased anxiety in response to threatening novel objects. Expand
High-fat maternal diet during pregnancy persistently alters the offspring microbiome in a primate model
TLDR
It is reported that a high-fat maternal or postnatal diet, but not obesity per se, structures the offspring’s intestinal microbiome in Macaca fuscata (Japanese macaque), and the resultant microbial dysbiosis is only partially corrected by a low-fat, control diet after weaning. Expand
Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion
TLDR
It is demonstrated that Ucn3 is stored and co-released with insulin and potentiates glucose-stimulated somatostatin secretion via cognate receptors on delta cells, which suggests that UCN3 is a key contributor to stable glycemic control, whose reduction during diabetes aggravates glycemic volatility and contributes to the pathophysiology of this disease. Expand
Regulation of food intake and gonadotropin-releasing hormone/luteinizing hormone during lactation: role of insulin and leptin.
TLDR
Results suggest that the negative energy balance of lactation is not required for the hyperphagic drive, although it is involved in the orexigenic changes in the ARH, which is most likely sustained by the induction of NPY in the DMH. Expand
Integration of the regulation of reproductive function and energy balance: lactation as a model
TLDR
The arcuate nucleus Neuropeptide Y (ARH-NPY) system provides a neuroanatomical framework by which to integrate changes in food intake/energy with the regulation of cyclic reproductive function. Expand
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