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filaggrin

Known as: Epidermal Filaggrin, Stratum corneum basic protein, filagrin 
Filaggrin (4061 aa, ~435 kDa) is encoded by the human FLG gene. This protein is involved in the structure of intermediate filaments.
National Institutes of Health

Related topics

Related topics

6 relations
FGFR1 geneFLG geneIntermediate FilamentsStructural gene

Broader (1)

Intermediate Filament Proteins

Narrower (1)

filament-aggregating protein, human

Papers overview

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Review
2012
Review
2012
Filaggrin mutations and the skin.
Filaggrin is very important in the terminal differentiation of the skin and the formation of cornified envelope in the stratum… 
2002
2002
Subcorneal colocalization of the small heat shock protein, hsp27, with keratins and proteins of the cornified cell envelope
Background hsp27 is a member of the small heat shock protein family. Its expression in epidermal keratinocytes in situ and in… 
2000
2000
Light and electron microscopical localization of filagrin-like immunoreactivity in normal and regenerating epidermis of the lizard Podarcis muralis.
In the stratum granulosum of mammalian epidermis, keratohyalin contains the histidine-rich protein filagrin which determines the… 
1995
1995
Rat epidermal cathepsin L-like proteinase: purification and some hydrolytic properties toward filaggrin and synthetic substrates.
We have purified cathepsin L-like proteinase from rat epidermis, determined its NH2-terminal amino acid sequence, and… 
1990
1990
Spreading of psoriatic plaques: alteration of epidermal differentiation precedes capillary leakiness and anomalies in vascular morphology.
To approach the temporal relationship between alterations in keratinization and capillary leakiness in psoriasis, we studied the… 
1988
1988
Filaggrin expression in normal and pathological skin
Filaggrin is a basic, histidine-rich protein synthesized by cells of keratinizing epithelia, that subserves major physiological… 
1985
1985
Multiple copies of phosphorylated filaggrin in epidermal profilaggrin demonstrated by analysis of tryptic peptides.
The precursor of mouse (c57/B16) epidermal filaggrin (profilaggrin) is a very large (ca. 500 000 daltons), highly phosphorylated… 
Highly Cited
1984
Highly Cited
1984
High-molecular-weight precursor of epidermal filaggrin and hypothesis for its tandem repeating structure.
Filaggrin is a histidine-rich protein that is intimately involved in mammalian epidermal keratinization. Using a combination of… 
1982
1982
Distribution of histidine-rich basic protein, a possible keratin matrix protein, in rat oral epithelium.
Highly Cited
1979
Highly Cited
1979
Evidence of a precursor form of stratum corneum basic protein in rat epidermis.
The fully differentiated anucleate cells of the stratum corneum of newborn rat epidermis contain a cationic protein called… 
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