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filaggrin

Known as: Epidermal Filaggrin, Stratum corneum basic protein, filagrin 
Filaggrin (4061 aa, ~435 kDa) is encoded by the human FLG gene. This protein is involved in the structure of intermediate filaments.
National Institutes of Health

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Highly Cited
2012
Highly Cited
2012
Abstract:  Atopic eczema and psoriasis are common skin diseases. While it is well established that the pathogenesis of these… Expand
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Highly Cited
2010
Highly Cited
2010
Loss-of-function mutations in the filaggrin gene are associated with ichthyosis vulgaris and atopic dermatitis. To investigate… Expand
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Highly Cited
2009
Highly Cited
2009
BACKGROUND Atopic dermatitis (AD) is a chronic inflammatory skin disease that is characterized by a defective skin barrier… Expand
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Highly Cited
2009
Highly Cited
2009
Filaggrin is a component of the cornified cell envelope and the precursor of free amino acids acting as a natural moisturizing… Expand
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Highly Cited
2007
Highly Cited
2007
BACKGROUND Atopic dermatitis (AD) is a chronic inflammatory skin disease that is characterized by a defective skin barrier… Expand
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Highly Cited
2007
Highly Cited
2007
BACKGROUND Filaggrin is a key protein involved in skin barrier function. Recently, mutations in the filaggrin gene, FLG, were… Expand
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Highly Cited
1999
Highly Cited
1999
Antifilaggrin autoantibodies (AFA) are a population of IgG autoantibodies associated to rheumatoid arthritis (RA), which includes… Expand
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Highly Cited
1995
Highly Cited
1995
The so-called antikeratin antibodies (AKA) and the antiperinuclear factor (APF) are the most specific serological markers of RA… Expand
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Highly Cited
1995
Highly Cited
1995
Skin irradiation with ultraviolet B (UVB) is a common and often durable treatment for psoriasis and other inflammatory skin… Expand
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Highly Cited
1993
Highly Cited
1993
In rheumatoid arthritis (RA), the high diagnostic value of serum antibodies to the stratum corneum of rat esophagus epithelium… Expand
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