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Dissociation of allergenic and immunogenic functions in contact sensitivity to para-phenylenediamine.
TLDR
In vitro results suggest that PPD is a prohapten which when applied on the skin is metabolized and converted into products (such as BB) which are the immunogenic haptens able to activate specific T cells.
Antikeratin antibodies in serum and synovial fluid show specificity for rheumatoid arthritis in a study of connective tissue diseases.
TLDR
A specific rabbit antihuman keratin antiserum was shown to have a different specificity from that of spontaneous human AKA, which was associated with the presence of subcutaneous nodules in RA but not with Raynaud's phenomenon, Sjögren's syndrome, or HLA-DR4 positivity.
Immunomorphological and ultrastructural aspects of keratinocyte migration in epidermal wound healing
TLDR
Transmission electron microscopy showed that the lamina densa was present across the wound hiatus and the development of desmosomes and hemidesmosomes during wound healing was demonstrated, which supports the hypothesis that the substances at the junctional zone are partly of epithelial origin.
Lectins as markers of human epidermal cell differentiation.
TLDR
Data indicate that the expression of lectin binding sites in normal epidermis differs according to the maturation of the cell from the basal cell to the more mature keratinocyte in the stratum granulosum, and suggest that lectins may be used as markers of epidermal cells in various stages of normal and abnormal differentiation.
Role of thiol compounds in mammalian melanin pigmentation: Part I. Reduced and oxidized glutathione.
TLDR
Results are consistent with the view that the activity of the enzyme glutathione reductase plays an important role in the regulation and control of the biosynthetic activity of melanocytes leading to various types of melanin pigments.
Brief report: successive occurrence of T-cell and B-cell lymphomas after renal transplantation in a patient with multiple cutaneous squamous-cell carcinomas.
TLDR
This case illustrates the role of immunosuppression in the development of multiple and complex malignant tumors and describes a renal-transplant recipient with multiple cutaneous warts and squamous-cell carcinomas in whom a cutaneous T-cell lymphoma (Sezary syndrome) later developed, followed by a nodal B- cell lymphoma with immunoblastic components.
IMMUNOINTERVENTION IN PSORIASIS WITH ANTI–CD4 ANTIBODIES
TLDR
It is suggested that therapies which are efficient in the treatment of chronic inflammatory and autoimmune dermatoses may be considered as immunosuppressive treatments that are able to block T cell activation.
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