figitumumab

A human monoclonal antibody directed against the insulin-like growth factor type I receptor (IGF1R) with potential antineoplastic activity… (More)
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
PURPOSE Figitumumab (CP-751,871), a fully human immunoglobulin G2 monoclonal antibody, inhibits the insulin-like growth factor 1… (More)
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2012
2012
PURPOSE Activation of the insulin-like growth factor 1 receptor (IGF-IR) is implicated in prostate cancer development and… (More)
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Highly Cited
2011
Highly Cited
2011
PURPOSE Preclinical models demonstrate synergistic antitumor activity with combination blockade of mTOR and IGF-1R signaling. We… (More)
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2011
2011
SummaryObjectives The insulin-like growth factor (IGF) signaling pathway has been implicated in the pathogenesis of numerous… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND Figitumumab is a fully human IgG2 monoclonal antibody targeting the insulin-like growth-factor-1 receptor (IGF-1R… (More)
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Highly Cited
2010
Highly Cited
2010
7500 Background: The Insulin-like growth factor type I receptor (IGF-IR) plays an important role in normal cellular growth and… (More)
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2010
2010
Antiangiogenic treatment activity has been reported in solitary fibrous tumor (SFT), a rare and little chemosensitive sarcoma. We… (More)
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Highly Cited
2009
Highly Cited
2009
PurposeInsulin-like growth factor 1 receptor signaling through upregulation of the stimulatory ligand IGF-II has been implicated… (More)
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Review
2009
Review
2009
Figitumumab (CP-751,871) is a fully human immunoglobulin G2 monoclonal antibody highly potent and specific against the insulin… (More)
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2009
2009
8091 Background: Signaling of Insulin like Growth Factors (IGFs) through the IGF type 1 receptor (IGF-IR) induces tumor… (More)
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