• Publications
  • Influence
Insulin and insulin-like growth factor signalling in neoplasia
  • M. Pollak
  • Medicine, Biology
    Nature Reviews Cancer
  • 1 December 2008
TLDR
Epidermiological, clinical and laboratory research methods are being used to investigate novel cancer prevention and treatment strategies related to insulin and IGF signalling, including the use of novel receptor-specific antibodies, receptor kinase inhibitors and AMP-activated protein kinase activators.
Insulin-like growth factors and neoplasia
TLDR
Converging results from epidemiological research and in vivo carcinogenesis models indicate that high levels of circulating IGF1 are associated with increased risk of several common cancers, and ongoing research seeks to clarify the mechanisms underlying these observations.
The insulin and insulin-like growth factor receptor family in neoplasia: an update
  • M. Pollak
  • Medicine, Biology
    Nature Reviews Cancer
  • 1 March 2012
TLDR
Clinical studies may benefit from the use of predictive biomarkers to identify probable responders, theUse of rational combination therapies and the consideration of alternative targeting strategies, such as ligand-specific antibodies and receptor-specific tyrosine kinase inhibitors.
Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin).
TLDR
In breast cancer cell models that overexpress HER2/neu, an increased level of IGF-IR signaling appears to interfere with the action of trastuzumab, and strategies that target IGF- IR signaling may prevent or delay development of resistance to trastzumab.
Metformin improves healthspan and lifespan in mice
TLDR
It is shown that long-term treatment with metformin starting at middle age extends healthspan and lifespan in male mice, while a higher dose (1% w/w) was toxic.
eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression
TLDR
It is shown that knock-in mice expressing a nonphosphorylatable form of eIF4E are resistant to tumorigenesis in a prostate cancer model, and the possibility that chemical compounds that prevent the phosphorylation of eif4E could act as anticancer drugs is raised.
Investigating metformin for cancer prevention and treatment: the end of the beginning.
  • M. Pollak
  • Medicine
    Cancer discovery
  • 1 September 2012
TLDR
There are tantalizing clues that justify the investigation of antineoplastic activities of biguanides, but the complexity of their biologic effects requires further translational research to guide clinical trial design.
Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells.
TLDR
It is shown here that metformin acts as a growth inhibitor rather than an insulin sensitizer for epithelial cells, which provides evidence for a mechanism that may contribute to the antineoplastic effects of met formin suggested by recent population studies and justifies further work to explore potential roles for activators of AMP kinase in cancer prevention and treatment.
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