CP 751871

Known as: CP-751,871, CP751,871, CP-751871 
A human monoclonal antibody directed against the insulin-like growth factor type I receptor (IGF1R) with potential antineoplastic activity. CP-751871… (More)
National Institutes of Health

Papers overview

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2015
2015
BACKGROUND Figitumumab (CP-751,871) is a fully human IgG2 monoclonal antibody that inhibits the insulin-like growth factor 1… (More)
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2012
2012
BACKGROUND Identification of predictive biomarkers is essential for the successful development of targeted therapy. Insulin-like… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND Figitumumab is a fully human IgG2 monoclonal antibody targeting the insulin-like growth-factor-1 receptor (IGF-1R… (More)
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Highly Cited
2009
Highly Cited
2009
PURPOSE We conducted a phase II study of combination of the anti-insulin-like growth factor 1 receptor antibody CP-751,871 with… (More)
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Highly Cited
2009
Highly Cited
2009
Signaling through the type 1 insulin-like growth factor receptor (IGF-1R) occurs in many human cancers, including childhood… (More)
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Review
2008
Review
2008
The mechanisms involved in the epithelial to mesenchymal transition (EMT) are integrated in concert with master developmental and… (More)
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Highly Cited
2008
Highly Cited
2008
PURPOSE A phase I first-in-human study was conducted to characterize the safety, tolerability, pharmacokinetic, and… (More)
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Highly Cited
2007
Highly Cited
2007
PURPOSE This phase I study was undertaken to define the maximum tolerated dose, safety, and pharmacokinetic profile of CP-751,871… (More)
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Highly Cited
2007
Highly Cited
2007
PURPOSE To detect insulin-like growth factor-IR (IGF-IR) on circulating tumor cells (CTC) as a biomarker in the clinical… (More)
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Highly Cited
2005
Highly Cited
2005
PURPOSE The insulin-like growth factor (IGF) signaling pathway is implicated in cellular mitogenesis, angiogenesis, tumor cell… (More)
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