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eukaryotic translation initiation factor 2 complex location

Known as: eIF-2, eIF2, eukaryotic translation initiation factor 2 complex 
Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to… 
National Institutes of Health

Related topics

Related topics

3 relations
EIF2S1 wt AlleleEIF2S3 geneEukaryotic Initiation Factor-2

Papers overview

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Highly Cited
2000
Highly Cited
2000
Identification of Caspase 3-mediated Cleavage and Functional Alteration of Eukaryotic Initiation Factor 2α in Apoptosis*
Induction of apoptosis in a variety of cell types leads to inhibition of protein synthesis. Recently, the cleavage of eukaryotic… 
Highly Cited
1998
Highly Cited
1998
Regulation of Guanine Nucleotide Exchange through Phosphorylation of Eukaryotic Initiation Factor eIF2α
The guanine nucleotide exchange activity of eIF2B plays a key regulatory role in the translation initiation phase of protein… 
Highly Cited
1996
Highly Cited
1996
Identification of a regulatory subcomplex in the guanine nucleotide exchange factor eIF2B that mediates inhibition by phosphorylated eIF2
Eukaryotic translation initiation factor 2B (eIF2B) is a five-subunit complex that catalyzes guanine nucleotide exchange on eIF2… 
Review
1991
Review
1991
Eukaryotic initiation factors eIF-2 and eIF-3: interactions, structure and localization in ribosomal initiation complexes.
Highly Cited
1989
Highly Cited
1989
Activation of double-stranded RNA-dependent kinase (dsl) by the TAR region of HIV-1 mRNA: A novel translational control mechanism
Highly Cited
1988
Highly Cited
1988
Phosphorylation of the guanine nucleotide exchange factor from rabbit reticulocytes regulates its activity in polypeptide chain initiation.
We have demonstrated that the purified guanine nine nucleotide exchange factor (GEF) may be isolated as a complex with NADPH… 
Highly Cited
1987
Highly Cited
1987
Regulation of polypeptide chain initiation in Chinese hamster ovary cells with a temperature-sensitive leucyl-tRNA synthetase. Changes in phosphorylation of initiation factor eIF-2 and in the…
Highly Cited
1983
Highly Cited
1983
A GDP/GTP exchange factor essential for eukaryotic initiation factor 2 cycling in Ehrlich ascites tumor cells and its regulation by eukaryotic initiation factor 2 phosphorylation.
Formation of the ternary complex Met-tRNAi X eukaryotic initiation factor (eIF) 2 X GTP from eIF-2 X GDP requires exchange of GDP… 
Highly Cited
1982
Highly Cited
1982
Phosphorylation inhibits guanine nucleotide exchange on eukaryotic initiation factor 2
There is extensive evidence that protein synthesis in reticulocyte lysates is inhibited during haem deficiency because of… 
Highly Cited
1982
Highly Cited
1982
Regulation of protein synthesis in vesicular stomatitis virus-infected mouse L-929 cells by decreased protein synthesis initiation factor 2 activity
Infection of mouse L-cell spinner cultures by vesicular stomatitis virus (VSV) effected the selective translation of viral mRNA… 
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