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eukaryotic translation initiation factor 2 complex location

Known as: eIF-2, eIF2, eukaryotic translation initiation factor 2 complex 
Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to… 
National Institutes of Health

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Related topics

3 relations
EIF2S1 wt AlleleEIF2S3 geneEukaryotic Initiation Factor-2

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
eIF2‐dependent and eIF2‐independent modes of initiation on the CSFV IRES: a common role of domain II
Specific interactions of the classical swine fever virus internal ribosomal entry site (IRES) with 40S ribosomal subunits and… 
Highly Cited
2005
Highly Cited
2005
Pi release from eIF2, not GTP hydrolysis, is the step controlled by start-site selection during eukaryotic translation initiation.
Highly Cited
2001
Highly Cited
2001
Multiple roles for the C‐terminal domain of eIF5 in translation initiation complex assembly and GTPase activation
eIF5 stimulates the GTPase activity of eIF2 bound to Met‐tRNAiMet, and its C‐terminal domain (eIF5‐CTD) bridges interaction… 
Highly Cited
2000
Highly Cited
2000
A multifactor complex of eukaryotic initiation factors, eIF1, eIF2, eIF3, eIF5, and initiator tRNA(Met) is an important translation initiation intermediate in vivo.
Translation initiation factor 2 (eIF2) bound to GTP transfers the initiator methionyl tRNA to the 40S ribosomal subunit. The eIF5… 
Highly Cited
2000
Highly Cited
2000
Phosphorylation of serine 51 in initiation factor 2 alpha (eIF2 alpha) promotes complex formation between eIF2 alpha(P) and eIF2B and causes inhibition in the guanine nucleotide exchange activity of…
Phosphorylation of serine 51 residue on the alpha-subunit of eukaryotic initiation factor 2 (eIF2alpha) inhibits the guanine… 
Highly Cited
1997
Highly Cited
1997
GTP hydrolysis controls stringent selection of the AUG start codon during translation initiation in Saccharomyces cerevisiae.
We have isolated and characterized two suppressor genes, SUI4 and SUI5, that can initiate translation in the absence of an AUG… 
Highly Cited
1995
Highly Cited
1995
Modulation of tRNA(iMet), eIF-2, and eIF-2B expression shows that GCN4 translation is inversely coupled to the level of eIF-2.GTP.Met-tRNA(iMet) ternary complexes
To understand how phosphorylation of eukaryotic translation initiation factor (eIF)-2 alpha in Saccharomyces cerevisiae… 
Highly Cited
1989
Highly Cited
1989
Activation of double-stranded RNA-dependent kinase (dsl) by the TAR region of HIV-1 mRNA: A novel translational control mechanism
Highly Cited
1983
Highly Cited
1983
A GDP/GTP exchange factor essential for eukaryotic initiation factor 2 cycling in Ehrlich ascites tumor cells and its regulation by eukaryotic initiation factor 2 phosphorylation.
Formation of the ternary complex Met-tRNAi X eukaryotic initiation factor (eIF) 2 X GTP from eIF-2 X GDP requires exchange of GDP… 
Highly Cited
1982
Highly Cited
1982
Phosphorylation inhibits guanine nucleotide exchange on eukaryotic initiation factor 2
There is extensive evidence that protein synthesis in reticulocyte lysates is inhibited during haem deficiency because of… 
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