eukaryotic translation initiation factor 2 complex location

Known as: eIF-2, eIF2, eukaryotic translation initiation factor 2 complex 
Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1977-2018
0519772018

Related topics

Related topics

3 relations
EIF2S1 wt AlleleEIF2S3 geneEukaryotic Initiation Factor-2

Related mentions per year

Related mentions per year

1975-2018
197019801990200020102020
eukaryotic translation initiation factor 2 complex location
Eukaryotic Initiation Factor-2
EIF2S1 wt Allele
EIF2S3 gene

Papers overview

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2008
2008
eIF2-dependent and eIF2-independent modes of initiation on the CSFV IRES: a common role of domain II.
Specific interactions of the classical swine fever virus internal ribosomal entry site (IRES) with 40S ribosomal subunits and… (More)
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Highly Cited
2006
Highly Cited
2006
Distinct induction patterns and functions of two closely related interferon-inducible human genes, ISG54 and ISG56.
Human P54 and P56 proteins are tetratricopeptide proteins that are encoded by two closely related genes, ISG54 and ISG56. These… (More)
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Highly Cited
2005
Highly Cited
2005
Pi release from eIF2, not GTP hydrolysis, is the step controlled by start-site selection during eukaryotic translation initiation.
Irreversible GTP hydrolysis by eIF2 is a critical step in translation initiation in eukaryotes because it is thought to commit… (More)
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Highly Cited
2002
Highly Cited
2002
Evidence that ternary complex (eIF2-GTP-tRNA(i)(Met))-deficient preinitiation complexes are core constituents of mammalian stress granules.
Environmental stress-induced phosphorylation of eIF2alpha inhibits protein translation by reducing the availability of eIF2-GTP… (More)
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2001
2001
Multiple roles for the C-terminal domain of eIF5 in translation initiation complex assembly and GTPase activation.
eIF5 stimulates the GTPase activity of eIF2 bound to Met-tRNA(i)(Met), and its C-terminal domain (eIF5-CTD) bridges interaction… (More)
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Highly Cited
2000
Highly Cited
2000
A multifactor complex of eukaryotic initiation factors, eIF1, eIF2, eIF3, eIF5, and initiator tRNA(Met) is an important translation initiation intermediate in vivo.
Translation initiation factor 2 (eIF2) bound to GTP transfers the initiator methionyl tRNA to the 40S ribosomal subunit. The eIF5… (More)
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Highly Cited
2000
Highly Cited
2000
The joining of ribosomal subunits in eukaryotes requires eIF5B
Initiation of eukaryotic protein synthesis begins with the ribosome separated into its 40S and 60S subunits. The 40S subunit… (More)
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Highly Cited
1999
Highly Cited
1999
Conserved bipartite motifs in yeast eIF5 and eIF2Bepsilon, GTPase-activating and GDP-GTP exchange factors in translation initiation, mediate binding to their common substrate eIF2.
In the initiation phase of eukaryotic translation, eIF5 stimulates the hydrolysis of GTP bound to eIF2 in the 40S ribosomal pre… (More)
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1999
1999
The dynamic role of GRP78/BiP in the coordination of mRNA translation with protein processing.
The role of GRP78/BiP in coordinating endoplasmic reticular (ER) protein processing with mRNA translation was examined in GH3… (More)
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1995
1995
Modulation of tRNA(iMet), eIF-2, and eIF-2B expression shows that GCN4 translation is inversely coupled to the level of eIF-2.GTP.Met-tRNA(iMet) ternary complexes.
To understand how phosphorylation of eukaryotic translation initiation factor (eIF)-2 alpha in Saccharomyces cerevisiae… (More)
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