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eukaryotic translation initiation factor 2 complex location

Known as: eIF-2, eIF2, eukaryotic translation initiation factor 2 complex 
Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to… Expand
National Institutes of Health

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3 relations
EIF2S1 wt AlleleEIF2S3 geneEukaryotic Initiation Factor-2

Papers overview

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Highly Cited
2017
Highly Cited
2017
Translation from unconventional 5′ start sites drives tumour initiation
We are just beginning to understand how translational control affects tumour initiation and malignancy. Here we use an epidermis… Expand
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Highly Cited
2012
Highly Cited
2012
The human translation initiation multi-factor complex promotes methionyl-tRNAi binding to the 40S ribosomal subunit
The delivery of Met-tRNAi to the 40S ribosomal subunit is thought to occur by way of a ternary complex (TC) comprising eIF2, GTP… Expand
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Highly Cited
2008
Highly Cited
2008
eIF2-dependent and eIF2-independent modes of initiation on the CSFV IRES: a common role of domain II.
Specific interactions of the classical swine fever virus internal ribosomal entry site (IRES) with 40S ribosomal subunits and… Expand
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Highly Cited
2005
Highly Cited
2005
Pi release from eIF2, not GTP hydrolysis, is the step controlled by start-site selection during eukaryotic translation initiation.
Irreversible GTP hydrolysis by eIF2 is a critical step in translation initiation in eukaryotes because it is thought to commit… Expand
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Highly Cited
2002
Highly Cited
2002
Evidence that ternary complex (eIF2-GTP-tRNA(i)(Met))-deficient preinitiation complexes are core constituents of mammalian stress granules.
Environmental stress-induced phosphorylation of eIF2alpha inhibits protein translation by reducing the availability of eIF2-GTP… Expand
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Highly Cited
2000
Highly Cited
2000
A multifactor complex of eukaryotic initiation factors, eIF1, eIF2, eIF3, eIF5, and initiator tRNA(Met) is an important translation initiation intermediate in vivo.
Translation initiation factor 2 (eIF2) bound to GTP transfers the initiator methionyl tRNA to the 40S ribosomal subunit. The eIF5… Expand
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Highly Cited
2000
Highly Cited
2000
Phosphorylation of serine 51 in initiation factor 2 alpha (eIF2 alpha) promotes complex formation between eIF2 alpha(P) and eIF2B and causes inhibition in the guanine nucleotide exchange activity of…
Phosphorylation of serine 51 residue on the alpha-subunit of eukaryotic initiation factor 2 (eIF2alpha) inhibits the guanine… Expand
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Highly Cited
1999
Highly Cited
1999
Conserved bipartite motifs in yeast eIF5 and eIF2Bepsilon, GTPase-activating and GDP-GTP exchange factors in translation initiation, mediate binding to their common substrate eIF2.
In the initiation phase of eukaryotic translation, eIF5 stimulates the hydrolysis of GTP bound to eIF2 in the 40S ribosomal pre… Expand
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Highly Cited
1998
Highly Cited
1998
Regulation of Guanine Nucleotide Exchange through Phosphorylation of Eukaryotic Initiation Factor eIF2α
The guanine nucleotide exchange activity of eIF2B plays a key regulatory role in the translation initiation phase of protein… Expand
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Highly Cited
1997
Highly Cited
1997
GTP hydrolysis controls stringent selection of the AUG start codon during translation initiation in Saccharomyces cerevisiae.
We have isolated and characterized two suppressor genes, SUI4 and SUI5, that can initiate translation in the absence of an AUG… Expand
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