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Top 100 relevant results, sorted by most influential
Macrophage Diversity Enhances Tumor Progression and Metastasis
There is persuasive clinical and experimental evidence that macrophages promote cancer initiation and malignant progression. During tumor initiation, they create an inflammatory environment that is… Expand
Macrophage biology in development, homeostasis and disease
Macrophages, the most plastic cells of the haematopoietic system, are found in all tissues and show great functional diversity. They have roles in development, homeostasis, tissue repair and… Expand
A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
Macrophage Development Rewritten Macrophages provide protection against a wide variety of infections and critically shape the inflammatory environment in many tissues. These cells come in many… Expand
Microenvironmental regulation of metastasis
Metastasis is a multistage process that requires cancer cells to escape from the primary tumour, survive in the circulation, seed at distant sites and grow. Each of these processes involves… Expand
CCL2 recruits inflammatory monocytes to facilitate breast tumor metastasis
Macrophages, which are abundant in the tumour microenvironment, enhance malignancy. At metastatic sites, a distinct population of metastasis-associated macrophages promotes the extravasation, seeding… Expand
Tumour-educated macrophages promote tumour progression and metastasis
- J. Pollard
- Biology, Medicine
- Nature Reviews Cancer
Evidence from clinical and experimental studies indicates that macrophages promote solid-tumour progression and metastasis. Macrophages are educated by the tumour microenvironment, so that they adopt… Expand
Tumor-associated macrophages: from mechanisms to therapy.
The tumor microenvironment is a complex ecology of cells that evolves with and provides support to tumor cells during the transition to malignancy. Among the innate and adaptive immune cells… Expand
Distinct role of macrophages in different tumor microenvironments.
Macrophages are prominent in the stromal compartment of virtually all types of malignancy. These highly versatile cells respond to the presence of stimuli in different parts of tumors with the… Expand
Colony-Stimulating Factor 1 Promotes Progression of Mammary Tumors to Malignancy
- E. Lin, A. Nguyen, R. Russell, J. Pollard
- Biology, Medicine
- The Journal of experimental medicine
- 19 March 2001
In human breast carcinomas, overexpression of the macrophage colony–stimulating factor (CSF-1) and its receptor (CSF-1R) correlates with poor prognosis. To establish if there is a causal relationship… Expand
Progression to malignancy in the polyoma middle T oncoprotein mouse breast cancer model provides a reliable model for human diseases.
- E. Lin, J. Jones, +4 authors J. Pollard
- Medicine, Biology
- The American journal of pathology
- 1 November 2003
Animal models are powerful tools to analyze the mechanism of the induction of human breast cancer. Here we report a detailed analysis of mammary tumor progression in one mouse model of breast cancer… Expand