• Publications
  • Influence
A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
TLDR
It is found that the transcription factor Myb was required for development of HSCs and all CD11bhigh monocytes and macrophages, but was dispensable for yolk sac (YS)macrophages and for the development of YS-derived F4/80bright macrophage populations in several tissues.
CCL2 recruits inflammatory monocytes to facilitate breast tumor metastasis
TLDR
The mechanistic link between CCL2 expression and macrophage infiltration are correlated with poor prognosis and metastatic disease in human breast cancer and the origin of these macrophages is defined by showing that Gr1-positive inflammatory monocytes are preferentially recruited to pulmonary metastases but not to primary mammary tumours in mice.
Macrophage biology in development, homeostasis and disease
TLDR
This Review discusses how macrophage regulate normal physiology and development, and provides several examples of their pathophysiological roles in disease, and defines the ‘hallmarks’ of macrophages according to the states that they adopt during the performance of their various roles.
Microenvironmental regulation of metastasis
TLDR
Experimental data demonstrating the role of the microenvironment in metastasis is described, areas for future research are identified and possible new therapeutic avenues are suggested.
Tumour-educated macrophages promote tumour progression and metastasis
TLDR
Macrophages are educated by the tumour microenvironment, so that they adopt a trophic role that facilitates angiogenesis, matrix breakdown and tumour-cell motility — all of which are elements of the metastatic process.
Distinct role of macrophages in different tumor microenvironments.
TLDR
The evidence for differential regulation of TAMs in these microenvironments is discussed and an overview of current attempts to target or use TAMs for therapeutic purposes is provided.
Colony-Stimulating Factor 1 Promotes Progression of Mammary Tumors to Malignancy
TLDR
It is demonstrated that the growth of mammary tumors and the development to malignancy are separate processes and that CSF-1 selectively promotes the latter process, and that agents directed at CSf-1/CSF- 1R activity could have important therapeutic effects.
...
...