eritoran

Known as: 3-O-decyl-2-deoxy-6-O-(2-deoxy-3-O-(3-methoxydecyl)-6-O-methyl-2-((1-oxo-11-octadecenyl)amino)-4-O-phosphonoglucopyranosyl)-2-((1,3-dioxotetradecyl)amino)-1-(dihydroxy phosphate)glucopyranose 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2004-2018
0246820042018

Papers overview

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Review
2016
Review
2016
Toll-like receptors (TLRs) have been shown to play an important role in the immune system, which warrants study of their… (More)
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Highly Cited
2013
Highly Cited
2013
There is a pressing need to develop alternatives to annual influenza vaccines and antiviral agents licensed for mitigating… (More)
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Highly Cited
2013
Highly Cited
2013
IMPORTANCE Eritoran is a synthetic lipid A antagonist that blocks lipopolysaccharide (LPS) from binding at the cell surface MD2… (More)
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2013
2013
BACKGROUND Severe injury and associated hemorrhagic shock lead to an inflammatory response and subsequent increased tissue damage… (More)
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2011
2011
AIMS Toll-like receptor 4 (TLR4) recognizes lipopolysaccharides and endogenous ligands released after organ injury. Deficiency of… (More)
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Highly Cited
2010
Highly Cited
2010
OBJECTIVES Endotoxin is a potent stimulus of proinflammatory response and systemic coagulation in patients with severe sepsis… (More)
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2010
2010
BACKGROUND Ischemia-reperfusion injury (I/R) has a negative effect on renal allograft survival. Using a rat model of kidney IR… (More)
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2009
2009
PURPOSE To investigate the role of the TLR4/MD-2 antagonist eritoran tetrasodium in a murine model of contact lens-associated… (More)
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Highly Cited
2007
Highly Cited
2007
TLR4 and MD-2 form a heterodimer that recognizes LPS (lipopolysaccharide) from Gram-negative bacteria. Eritoran is an analog of… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND We previously reported that the functional mutation of Toll-like receptor 4 (TLR4) in C3H/HeJ mice subjected to… (More)
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