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E5564

Known as: E 5564, E-5564 
National Institutes of Health

Related topics

Related topics

5 relations
B 1287analogs & derivativeseritoran

Broader (2)

Eritoran TetrasodiumLipid A

Papers overview

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Highly Cited
2015
Highly Cited
2015
Toll-like Receptor 4 (TLR4) Antagonist Eritoran Tetrasodium Attenuates Liver Ischemia and Reperfusion Injury through Inhibition of High-Mobility Group Box Protein B1 (HMGB1) Signaling
Toll-like receptor 4 (TLR4) is ubiquitously expressed on parenchymal and immune cells of the liver and is the most studied TLR… 
Highly Cited
2012
Highly Cited
2012
Respiratory Syncytial Virus Fusion Protein-Induced Toll-Like Receptor 4 (TLR4) Signaling Is Inhibited by the TLR4 Antagonists Rhodobacter sphaeroides Lipopolysaccharide and Eritoran (E5564) and…
ABSTRACT Respiratory syncytial virus (RSV) is a leading cause of infant mortality worldwide. Toll-like receptor 4 (TLR4), a… 
Review
2011
Review
2011
Eritoran tetrasodium (E5564) treatment for sepsis: review of preclinical and clinical studies
Introduction: Sepsis remains a leading cause of death worldwide. Despite years of extensive research, effective drugs that… 
Review
2011
Review
2011
Role of toll-like receptors in cardiovascular diseases.
The discovery and characterization of the TLR (Toll-like receptor) family has led to a better understanding of the innate immune… 
Review
2011
Review
2011
Peptide-based treatment of sepsis
Sepsis (blood poisoning) is a severe infectious disease with high mortality, and no effective therapy is actually known. In the… 
2008
2008
Inhibition of corneal inflammation by the TLR4 antagonist Eritoran tetrasodium (E5564).
PURPOSE To investigate the role of the TLR4/MD-2 antagonist eritoran tetrasodium in a murine model of contact lens-associated… 
Highly Cited
2006
Highly Cited
2006
E5564 (Eritoran) inhibits lipopolysaccharide-induced cytokine production in human blood monocytes
Abstract.Objective and designIn this ex vivo laboratory study, we investigated the effects of E5564 (eritoran), a toll-like… 
Review
2005
Review
2005
TLR4 antagonists for endotoxemia and beyond.
Toll-like receptor 4 (TLR4) controls the major responding signaling system that detects the presence of Gram-negative infectious… 
Highly Cited
2004
Highly Cited
2004
Safety, Pharmacokinetics, Pharmacodynamics, and Plasma Lipoprotein Distribution of Eritoran (E5564) during Continuous Intravenous Infusion into Healthy Volunteers
ABSTRACT Eritoran, a structural analogue of the lipid A portion of lipopolysaccharide (LPS), is an antagonist of LPS in animal… 
2004
2004
Extended in Vivo Pharmacodynamic Activity of E5564 in Normal Volunteers with Experimental Endotoxemia
E5564 (α-d-glucopyranose) is a synthetic antagonist of bacterial endotoxin that has been shown to completely block human… 
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