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Geranylgeranylacetone induces heat shock proteins in cultured guinea pig gastric mucosal cells and rat gastric mucosa.
TLDR
The administration of GGA additionally enhanced the heat shock response and reduced ulcer formation in rats subjected to restraint and water-immersion stress, and this novel action may increase gastric mucosal defense at conditions of stress.
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Novel epoxysuccinyl peptides Selective inhibitors of cathepsin B, in vitro
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Novel epoxysuccinyl peptides A selective inhibitor of cathepsin B, in vivo
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Osteoactivin upregulates expression of MMP-3 and MMP-9 in fibroblasts infiltrated into denervated skeletal muscle in mice.
TLDR
The present results suggest that osteoactivin might function as an activator for fibroblasts infiltrated into denervated skeletal muscles and play an important role in regulating degeneration/regeneration of extracellular matrix.
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Space shuttle flight (STS‐90) enhances degradation of rat myosin heavy chain in association with activation of ubiquitin‐proteasome pathway
TLDR
The results suggest that spaceflight induces the degradation of muscle contractile proteins, including MHC, possibly through a ubiquitin‐dependent proteolytic pathway.
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Skeletal muscle gene expression in space‐flown rats
TLDR
It is postulate that mitochondrial dislocation during spaceflight has deleterious effects on muscle fibers, leading to atrophy in the form of insufficient energy provision for construction and leakage of reactive oxygen species from the mitochondria.
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The potential of GPNMB as novel neuroprotective factor in amyotrophic lateral sclerosis
TLDR
Glycoprotein nonmetastatic melanoma protein B can be a target for therapeutic intervention for suppressing motor neuron degeneration in ALS, and expression was substantial in the sera of sporadic ALS patients than that of other diseased patients.
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Ubiquitin Ligase Cbl-b Is a Negative Regulator for Insulin-Like Growth Factor 1 Signaling during Muscle Atrophy Caused by Unloading
TLDR
The results indicate that the Cbl-b-dependent destruction of IRS-1 is a critical dual mediator of both increased protein degradation and reduced protein synthesis observed in unloading-induced muscle atrophy.
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Toll-like receptor 4 regulates gastric pit cell responses to Helicobacter pylori infection.
TLDR
Investigation of expression levels of several key members of the Toll-like receptor (TLR) family in primary cultures of guinea pig gastric pit cells suggest that TLR4 may play a crucial role in the initiation of inflammatory responses of gastric Pit cells against Hp infection.
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Osteoactivin fragments produced by ectodomain shedding induce MMP‐3 expression via ERK pathway in mouse NIH‐3T3 fibroblasts
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