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Immunodesign of experimental sepsis by cecal ligation and puncture
Standardized procedures for inducing sepsis in mice and rats are defined by applying defined severity grades of sepsi through modulation of the position of cecal ligation. Expand
Harmful molecular mechanisms in sepsis
This Review highlights recent insights into the molecular interactions that occur during sepsis and attempts to unravel the nature of the dysregulated immune response duringSepsis. Expand
Role of C5a in inflammatory responses.
Accumulating data suggest that C5a provides a vital bridge between innate and adaptive immune functions, extending the roles of C5o in inflammation. Expand
Novel strategies for the treatment of sepsis
The history of therapeutic interventions in clinical trials for sepsis has been referred to as the “graveyard for pharmaceutical companies.” That is now set to change, as research provides hope for… Expand
Adhesion molecules and inflammatory injury
- S. Albelda, C. Wayne Smith, P. Ward
- Chemistry, Medicine
- FASEB journal : official publication of the…
- 1 May 1994
These studies demonstrate that CAM blockade can effectively inhibit inflammation; however, there appear to be clear differences in the adhesion requirements for particular types of inflammation. Expand
The NLR gene family: a standard nomenclature.
This work collectively proposes the family designation NLR (nucleotide-binding domain and leucine-rich repeat containing) and provides unique and standardized gene designations for all family members. Expand
The dark side of C5a in sepsis
- P. Ward
- Nature Reviews Immunology
- 1 February 2004
The present understanding of how and why sepsis is a life-threatening condition and how it might be more effectively treated is described. Expand
Phagocyte-derived catecholamines enhance acute inflammatory injury
Phagocytes are identified as a new source of catecholamines, which enhance the inflammatory response, and the presence of the complete intracellular machinery for the generation, release and inactivation of ctcholamines is shown. Expand
The enigma of sepsis.
The search for effective therapeutic interventions, hurdles in translational sepsis research, and new therapies in development in current clinical trials are discussed. Expand
Generation of C5a in the absence of C3: a new complement activation pathway
The data suggest that, in the genetic absence of C3, thrombin substitutes for the C3-dependent C5 convertase, and may represent a new pathway of complement activation. Expand