ellipticine

Known as: 5,11-dimethyl-6H-pyrido(4,3-b)carbazole 
 
National Institutes of Health

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Highly Cited
2004
Highly Cited
2004
To establish a method for predicting polymer-drug compatibility as a means to guide formulation development, we carried out… (More)
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Highly Cited
2004
Highly Cited
2004
Ellipticine is an antineoplastic agent, the mode of action of which is considered to be based on DNA intercalation and inhibition… (More)
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2004
2004
Anticancer drugs often show complex mechanisms of action, including effects on multiple cellular targets. Detailed understanding… (More)
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Highly Cited
2004
Highly Cited
2004
The performance of alamar blue and 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) cell viability assays in a… (More)
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Highly Cited
2003
Highly Cited
2003
Several anticancer drugs target DNA or enzymes acting on the DNA. Because chromatin DNA is tightly compacted, accessibility to… (More)
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Highly Cited
2003
Highly Cited
2003
The p53 tumor suppressor is frequently inactivated in tumors by point mutations in the DNA-binding domain, resulting in loss of… (More)
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2003
2003
Ellipticine is a potent antineoplastic agent whose mode of action is considered to be based mainly on DNA intercalation and/or… (More)
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Highly Cited
1984
Highly Cited
1984
Many intercalative antitumor drugs have been shown to induce reversible protein-linked DNA breaks in cultured mammalian cells… (More)
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Highly Cited
1978
Highly Cited
1978
The effect of intercalating agents on mammalian DNA in vivo was examined by the technique of alkaline elution. Adriamycin and… (More)
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1975
1975
Ellipticine (NSC 71795), a plant alkaloid with antitumor activity, is a weakly basic polycyclic molecule with dimensions similar… (More)
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