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ellipticine

Known as: 5,11-dimethyl-6H-pyrido(4,3-b)carbazole 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (3)

Antineoplastic AgentsEllipticinesUncoupling Agents

Narrower (3)

NSC 71795ellipticine hydrochlorideellipticine tartrate

Papers overview

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Highly Cited
2008
Highly Cited
2008
Sequence Effect of Self-Assembling Peptides on the Complexation and In Vitro Delivery of the Hydrophobic Anticancer Drug Ellipticine
A special class of self-assembling peptides has been found to be capable of stabilizing the hydrophobic anticancer agent… 
2005
2005
Molecular modeling of wild-type and D816V c-Kit inhibition based on ATP-competitive binding of ellipticine derivatives to tyrosine kinases.
The D816V activating mutation of the c-Kit kinase domain often causes human mastocytosis. Although inhibitors of wild-type c-Kit… 
2005
2005
Antitumor drug ellipticine inhibits the activities of rat hepatic cytochromes P450.
Ellipticine is a potent antineoplastic agent, whose mode of action is considered to be based mainly on DNA intercalation and/or… 
2001
2001
N-(2-hydroxypropyl)methacrylamide copolymer-6-(3-aminopropyl)-ellipticine conjugates. Synthesis, in vitro, and preliminary in vivo evaluation.
Ellipticine derivatives have potential as anticancer drugs. Their clinical use has been limited, however, by poor solubility and… 
Highly Cited
2000
Highly Cited
2000
Synthesis of 6H-indolo[2,3-b][1,6]naphthyridines and related compounds as the 5-Aza analogues of ellipticine alkaloids.
Treatment of 2-(1-alkynyl)phenyl isocyanates 6 with the iminophosphorane 14 produced in situ the benzoenynyl carbodiimides 15… 
1997
1997
Synthesis, DNA binding, and cleaving properties of an ellipticine-salen.copper conjugate.
The synthesis of a DNA-cutting agent that conjugates an ellipticine chromophore and a copper complex of bis(salicylidene… 
1992
1992
Molecular analysis of mutations induced by the intercalating agent ellipticine at the hisd3052 allele of salmonella typhimurium TA98
We have used DNA colony hybridization, the polymerase chain reaction (PCR), and direct DNA sequencing to determine the mutations… 
1992
1992
Binding of a distamycin-ellipticine hybrid molecule to DNA and chromatin: spectroscopic, biochemical, and molecular modeling investigations.
A bifunctional molecule in which an ellipticine chromophore is attached to a distamycin residue via a diaminopropyl tether has… 
Highly Cited
1991
Highly Cited
1991
Sequence requirements for mammalian topoisomerase II mediated DNA cleavage stimulated by an ellipticine derivative.
Various antitumor drugs stabilize DNA topoisomerase II-DNA transient covalent complexes. The complexes distribution along pBR322… 
1986
1986
Basically substituted ellipticine analogues as potential antitumor agents.
Installation of a basic side chain on the ring nitrogen of ellipticine did, as expected, improve the DNA binding properties of… 
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