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Ellipticines

Known as: Ellipticines [Chemical/Ingredient] 
Pyrido-CARBAZOLES originally discovered in the bark of OCHROSIA ELLIPTICA. They inhibit DNA and RNA synthesis and have immunosuppressive properties.
National Institutes of Health

Related topics

Related topics

33 relations

Narrower (23)

12-hydroxyellipticine13-hydroxyellipticine13-oxoellipticine2-methylellipticinium

Broader (2)

Antineoplastic Agents, PhytogenicImmunosuppressive Agents
In BloodProcess of secretionagonistsantagonists & inhibitors

Papers overview

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2001
2001
Screening for and identification of novel agents directed at renal cell carcinoma.
We were interested in identifying novel agents for renal cell carcinoma (RCC) by screening for activities that model renal tumor… 
1997
1997
Structure-activity relationship for DNA topoisomerase II-induced DNA cleavage by azatoxin analogues.
Review
1994
Review
1994
Clinical development of topoisomerase-interactive drugs.
1994
1994
Cellular uptake as a determinant of cytotoxicity of quaternized ellipticines to human brain tumor cells.
The quaternized ellipticine derivative, 9-methoxy-N2-methylellipticinium acetate (MMEA), is representative of a group of… 
1994
1994
Design, synthesis, and study of 9-substituted ellipticine and 2-methylellipticinium analogues as potential CNS-selective antitumor agents.
N,N-Dimethylformamide (DMF) dineopentyl acetal-mediated O-alkylations of 9-hydroxyellipticine gave 9-ethoxy-, 9-(1-methylethoxy… 
1988
1988
A comparative model membrane study on structural effects of membrane-active positively charged anti-tumor drugs.
1988
1988
Binding characteristics of 4-S proteins from rat and mouse liver. High affinity of ellipticines.
The binding characteristics of 4-S components (carcinogen-binding protein) from livers of Sprague-Dawley rats, C57BL/6 and DBA/2… 
Highly Cited
1980
Highly Cited
1980
DNA intercalating compounds as potential antitumor agents. 1. Preparation and properties of 7H-pyridocarbazoles.
The DNA intercalating compounds derived from 6H-pyridocarbazole (ellipticines, olivacines) elicit high antitumor properties. In… 
Highly Cited
1979
Highly Cited
1979
A class of strong inhibitors of microsomal monooxygenases: the ellipticines.
1977
1977
A new approach to the synthesis of ellipticines.
1,4-Dimethylcarbazole-3-carbaldehyde (2a) was condensed with aminoacetaldehyde diethyl acetal, and the Schiff's base was… 
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