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12-hydroxyellipticine

National Institutes of Health

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Broader (1)

Ellipticines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Cytochrome b5 increases cytochrome P450 3A4-mediated activation of anticancer drug ellipticine to 13-hydroxyellipticine whose covalent binding to DNA is elevated by sulfotransferases and N,O…
The antineoplastic alkaloid ellipticine is a prodrug, whose pharmacological efficiency is dependent on its cytochrome P450 (P450… 
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2012
2012
Ellipticine oxidation and DNA adduct formation in human hepatocytes is catalyzed by human cytochromes P450 and enhanced by cytochrome b5.
Ellipticine is an antineoplastic agent considered a pro-drug, the pharmacological and genotoxic effects of which are dependent on… 
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Review
2011
Review
2011
Cytochrome P450- and peroxidase-mediated oxidation of anticancer alkaloid ellipticine dictates its anti-tumor efficiency.
An antineoplastic alkaloid ellipticine is a prodrug, whose pharmacological efficiency is dependent on its cytochrome P450 (CYP… 
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Highly Cited
2011
Highly Cited
2011
Ellipticine cytotoxicity to cancer cell lines — a comparative study
Ellipticine cytotoxicity to cancer cell lines - a comparative study Ellipticine is a potent antineoplastic agent exhibiting… 
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Highly Cited
2009
Highly Cited
2009
The mechanism of cytotoxicity and DNA adduct formation by the anticancer drug ellipticine in human neuroblastoma cells.
Ellipticine is an antineoplastic agent, whose mode of action is based mainly on DNA intercalation, inhibition of topoisomerase II… 
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Highly Cited
2007
Highly Cited
2007
Mammalian peroxidases activate anticancer drug ellipticine to intermediates forming deoxyguanosine adducts in DNA identical to those found in vivo and generated from 12‐hydroxyellipticine and 13…
Ellipticine is a potent antineoplastic agent, whose mode of action is considered to be based mainly on DNA intercalation… 
2007
2007
DNA adduct formation by the anticancer drug ellipticine in human leukemia HL-60 and CCRF-CEM cells.
Ellipticine induces formation of two DNA adducts in leukemia HL-60 and CCRF-CEM cells, identical with deoxyguanosine adducts… 
Review
2006
Review
2006
Molecular mechanisms of antineoplastic action of an anticancer drug ellipticine.
Ellipticine is a potent antineoplastic agent exhibiting the multimodal mechanism of its action. This article reviews the… 
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2006
2006
Oxidation pattern of the anticancer drug ellipticine by hepatic microsomes - similarity between human and rat systems.
Ellipticine is an antineoplastic agent, whose mode of action is based mainly on DNA intercalation, inhibition of topoisomerase II… 
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Highly Cited
2004
Highly Cited
2004
The Anticancer Drug Ellipticine Forms Covalent DNA Adducts, Mediated by Human Cytochromes P450, through Metabolism to 13-Hydroxyellipticine and Ellipticine N2-Oxide
Ellipticine is an antineoplastic agent, the mode of action of which is considered to be based on DNA intercalation and inhibition… 
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