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12-hydroxyellipticine

National Institutes of Health

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Ellipticines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Cytochrome b5 plays a dual role in the reaction cycle of cytochrome P450 3A4 during oxidation of the anticancer drug ellipticine
Ellipticine is an anticancer agent that forms covalent DNA adducts after enzymatic activation by cytochrome P450 (CYP) enzymes… 
2016
2016
Heterologous expression of human cytochrome P450 2S1 in Escherichia coli and investigation of its role in metabolism of benzo[a]pyrene and ellipticine
Cytochrome P450 (CYP) 2S1 is “orphan” CYP that is overexpressed in several epithelial tissues and many human tumors. The pure… 
Review
2015
Review
2015
The Anticancer Drug Ellipticine Activated with Cytochrome
Ellipticine is a DNA-damaging agent acting as a prodrug whose 23 pharmacological efficiencies and genotoxic side effects are… 
Review
2014
Review
2014
The Anticancer Drug Ellipticine Activated with Cytochrome P450 Mediates DNA Damage Determining Its Pharmacological Efficiencies: Studies with Rats, Hepatic Cytochrome P450 Reductase Null (HRN™) Mice…
Ellipticine is a DNA-damaging agent acting as a prodrug whose pharmacological efficiencies and genotoxic side effects are… 
2012
2012
Cytochrome b5 increases cytochrome P450 3A4-mediated activation of anticancer drug ellipticine to 13-hydroxyellipticine whose covalent binding to DNA is elevated by sulfotransferases and N,O…
The antineoplastic alkaloid ellipticine is a prodrug, whose pharmacological efficiency is dependent on its cytochrome P450 (P450… 
2012
2012
Analysis of covalent ellipticine- and doxorubicin-derived adducts in DNA of neuroblastoma cells by the ³²P-postlabeling technique.
BACKGROUND Ellipticine and doxorubicin are antineoplastic agents, whose action is based mainly on DNA damage such as… 
Review
2011
Review
2011
Cytochrome P450- and peroxidase-mediated oxidation of anticancer alkaloid ellipticine dictates its anti-tumor efficiency.
Highly Cited
2011
Highly Cited
2011
Ellipticine cytotoxicity to cancer cell lines — a comparative study
Ellipticine cytotoxicity to cancer cell lines - a comparative study Ellipticine is a potent antineoplastic agent exhibiting… 
Highly Cited
2009
Highly Cited
2009
The mechanism of cytotoxicity and DNA adduct formation by the anticancer drug ellipticine in human neuroblastoma cells.
2009
2009
Cytotoxicity of and DNA adduct formation by ellipticine in human U87MG glioblastoma cancer cells.
OBJECTIVES Ellipticine is a potent antineoplastic agent exhibiting multiple mechanisms of action with promising brain tumor… 
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