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12-hydroxyellipticine
National Institutes of Health
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1 relation
Broader (1)
Ellipticines
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Cytochrome b5 increases cytochrome P450 3A4-mediated activation of anticancer drug ellipticine to 13-hydroxyellipticine whose covalent binding to DNA is elevated by sulfotransferases and N,O…
M. Stiborová
,
R. Indra
,
+6 authors
E. Frei
Chemical research in toxicology
2012
Corpus ID: 37290825
The antineoplastic alkaloid ellipticine is a prodrug, whose pharmacological efficiency is dependent on its cytochrome P450 (P450…
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2012
2012
Ellipticine oxidation and DNA adduct formation in human hepatocytes is catalyzed by human cytochromes P450 and enhanced by cytochrome b5.
M. Stiborová
,
J. Poljaková
,
+4 authors
E. Frei
Toxicology
2012
Corpus ID: 205428169
Ellipticine is an antineoplastic agent considered a pro-drug, the pharmacological and genotoxic effects of which are dependent on…
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2011
2011
Ellipticine cytotoxicity to cancer cell lines — a comparative study
M. Stiborová
,
J. Poljaková
,
+4 authors
E. Frei
Interdisciplinary toxicology
2011
Corpus ID: 6897707
Ellipticine cytotoxicity to cancer cell lines - a comparative study Ellipticine is a potent antineoplastic agent exhibiting…
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Highly Cited
2009
Highly Cited
2009
The mechanism of cytotoxicity and DNA adduct formation by the anticancer drug ellipticine in human neuroblastoma cells.
J. Poljaková
,
T. Eckschlager
,
+6 authors
M. Stiborová
Biochemical pharmacology
2009
Corpus ID: 10514156
Ellipticine is an antineoplastic agent, whose mode of action is based mainly on DNA intercalation, inhibition of topoisomerase II…
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2009
2009
Cytotoxicity of and DNA adduct formation by ellipticine in human U87MG glioblastoma cancer cells.
E. Martínková
,
M. Dontenwill
,
E. Frei
,
M. Stiborová
Neuro endocrinology letters
2009
Corpus ID: 26375368
OBJECTIVES Ellipticine is a potent antineoplastic agent exhibiting multiple mechanisms of action with promising brain tumor…
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Highly Cited
2007
Highly Cited
2007
Mammalian peroxidases activate anticancer drug ellipticine to intermediates forming deoxyguanosine adducts in DNA identical to those found in vivo and generated from 12‐hydroxyellipticine and 13…
M. Stiborová
,
J. Poljaková
,
H. Ryšlavá
,
M. Dračínský
,
T. Eckschlager
,
E. Frei
International journal of cancer
2007
Corpus ID: 23284969
Ellipticine is a potent antineoplastic agent, whose mode of action is considered to be based mainly on DNA intercalation…
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2007
2007
DNA adduct formation by the anticancer drug ellipticine in human leukemia HL-60 and CCRF-CEM cells.
J. Poljaková
,
E. Frei
,
+4 authors
M. Stiborová
Cancer letters
2007
Corpus ID: 25365379
Ellipticine induces formation of two DNA adducts in leukemia HL-60 and CCRF-CEM cells, identical with deoxyguanosine adducts…
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2007
2007
The Anticancer Drug Ellipticine Is a Potent Inducer of Rat Cytochromes P450 1A1 and 1A2, Thereby Modulating Its Own Metabolism
D. Aimová
,
L. Svobodová
,
+6 authors
M. Stiborová
Drug Metabolism and Disposition
2007
Corpus ID: 747603
Ellipticine is an antineoplastic agent whose mode of action is based mainly on DNA intercalation, inhibition of topoisomerase II…
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2006
2006
Oxidation pattern of the anticancer drug ellipticine by hepatic microsomes - similarity between human and rat systems.
M. Stiborová
,
L. Bořek-Dohalská
,
+7 authors
E. Frei
General physiology and biophysics
2006
Corpus ID: 34109391
Ellipticine is an antineoplastic agent, whose mode of action is based mainly on DNA intercalation, inhibition of topoisomerase II…
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Highly Cited
2004
Highly Cited
2004
The Anticancer Drug Ellipticine Forms Covalent DNA Adducts, Mediated by Human Cytochromes P450, through Metabolism to 13-Hydroxyellipticine and Ellipticine N2-Oxide
M. Stiborová
,
J. Sejbal
,
+8 authors
E. Frei
Cancer Research
2004
Corpus ID: 23287884
Ellipticine is an antineoplastic agent, the mode of action of which is considered to be based on DNA intercalation and inhibition…
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