• Publications
  • Influence
Urothelial carcinoma associated with the use of a Chinese herb (Aristolochia fangchi)
The prevalence of urothelial carcinoma among patients with end-stage Chinese-herb nephropathy (caused by aristolochia species) is a high. Expand
Aristolochic acid as a probable human cancer hazard in herbal remedies: a review.
It is concluded that there is significant evidence that AA is a powerful nephrotoxic and carcinogenic substance with an extremely short latency period, not only in animals but also in humans. Expand
SOS induction of selected naturally occurring substances in Escherichia coli (SOS chromotest).
The SOS chromotest, using E. coli PQ37, was able to detect correctly most of the Salmonella mutagens and non-mutagens, and for 17 of 20 compounds, the results obtained could be compared to those obtained in the Ames test. Expand
Time- and concentration-dependent changes in gene expression induced by benzo(a)pyrene in two human cell lines, MCF-7 and HepG2
It is demonstrated that investigating the time and concentration effect of a carcinogen on gene expression related to other biological end-points gives greater insight into cellular responses to such compounds and strengthens the identification of target genes. Expand
AHR- and DNA-damage-mediated gene expression responses induced by benzo(a)pyrene in human cell lines.
Some genes were modulated by BaP but not by TCDD or BPDE, including induction of CRY1 and MAK, which may represent novel signaling pathways that are independent of both AHR activation and DNA damage. Expand
3-Nitrobenzanthrone, a potential human cancer hazard in diesel exhaust and urban air pollution: a review of the evidence.
  • V. Arlt
  • Chemistry, Medicine
  • Mutagenesis
  • 1 November 2005
A critical review on the potential genotoxic effects of 3-NBA on human health is provided, concluding that these adducts not only represent premutagenic lesions in DNA but are of primary importance for the initiation of the carcinogenic process and subsequent tumour formation in target tissue. Expand
A Compendium of Mutational Signatures of Environmental Agents
This compendium of experimentally induced mutational signatures permits further exploration of roles of environmental agents in cancer etiology and underscores how human stem cell DNA is directly vulnerable to environmental agents. Expand
Molecular evidence for an involvement of organic anion transporters (OATs) in aristolochic acid nephropathy.
It is indicated that OATs can mediate the uptake of AA into proximal tubule cells and thereby participate in kidney cell damage by this toxin. Expand
Simultaneous Measurement of Benzo[a]pyrene-induced Pig-a and lacZ Mutations, Micronuclei and DNA Adducts in Muta™ Mouse
The similarity in dose response kinetics of Pig‐a and lacZ provides further evidence for the mutational origin of glycosylphosphatidylinositol (GPI)‐anchor deficiencies detected in the Pig‐ a assay. Expand
Balkan endemic nephropathy: an update on its aetiology
Recent molecular epidemiological studies provide a strong case that chronic dietary exposure to aristolochic acid (AA) a principal component of Aristolochia clematitis which grows as a weed in the wheat fields of the endemic regions is the cause of BEN and associated UUC. Expand