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ebselen

Known as: 2-phenyl-1,2-benzoisoselenazol-3(2H)-one 
A organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimetic and is… 
National Institutes of Health

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Related topics

9 relations

Broader (7)

Anti-Inflammatory Agents, Non-SteroidalAnti-Ulcer AgentAntioxidantsAzoles

Narrower (2)

DR 3305PZ 51

Papers overview

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Highly Cited
2015
Highly Cited
2015
Dexamethasone-induced apoptosis of osteocytic and osteoblastic cells is mediated by TAK1 activation.
Highly Cited
2012
Highly Cited
2012
Organotellurium and organoselenium compounds attenuate Mn-induced toxicity in Caenorhabditis elegans by preventing oxidative stress.
Highly Cited
2003
Highly Cited
2003
Diphenyl diselenide protects rat hippocampal slices submitted to oxygen–glucose deprivation and diminishes inducible nitric oxide synthase immunocontent
Highly Cited
2003
Highly Cited
2003
Organochalcogens effects on delta-aminolevulinate dehydratase activity from human erythrocytic cells in vitro.
Highly Cited
2003
Highly Cited
2003
Regulation of intrinsic prion protein by growth factors and TNF-alpha: the role of intracellular reactive oxygen species.
Highly Cited
2003
Highly Cited
2003
Methylmercury increases glutamate release from brain synaptosomes and glutamate uptake by cortical slices from suckling rat pups: modulatory effect of ebselen.
During the early postnatal period the brain is extremely sensitive to external agents. Here, we examined the effect of… 
Highly Cited
2003
Highly Cited
2003
Involvement of hydrogen peroxide in mistletoe lectin-II-induced apoptosis of myeloleukemic U937 cells.
2000
2000
Inhibition of ebselen on aflatoxin B(1)-induced hepatocarcinogenesis in Fischer 344 rats.
Aflatoxin B(1) (AFB(1)), a potent hepatocarcinogen, enhances ROS formation and causes oxidative DNA damage, which may play a role… 
Highly Cited
2000
Highly Cited
2000
Effect of three diaryl tellurides, and an organoselenium compound in trout erythrocytes exposed to oxidative stress in vitro.
Highly Cited
1996
Highly Cited
1996
The reaction of ebselen with peroxynitrite.
Ebselen, 2-phenyl-1,2-benzisoselenazol-3(2H)-one, rapidly reacts with peroxynitrite, the rate constant being of the order of 10(6… 
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