• Publications
  • Influence
Induction of colony-stimulating factor and stimulation of stem cell proliferation by injection of muroctasin.
Modulation of myelopoiesis by anomeric mixture of N2-[(N-acetylmuramoyl)-L-alanyl-D-isoglutamyl]-N6-stearoyl-L-lysin e (MDP-Lys(L18), muroctasin), a muramyl dipeptide analog, was investigated inExpand
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Immunopotentiation by a new antitumor polysaccharide, DMG, a degraded D-manno-D-glucan from Microellobosporia grisea culture fluid.
The immunopharmacological behavior of DMG, an antitumor polysaccharide, was studied in mice. DMG administered ip or sc stimulated peritoneal macrophages to produce high levels of interleukin-1Expand
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Specific binding sites of muroctasin on murine macrophages.
The specific binding sites for N2-[N-acetylmuramoyl)-L-alanyl-D-isoglutaminyl]-N6-stearoyl-L-lysine (MDP-Lys(L18), muroctasin), a synthetic muramyl dipeptide analog, on murine macrophages wereExpand
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Immunosuppressive effects of glycosylation inhibiting factor on the IgE and IgG antibody response.
Glycosylation inhibiting factor (GIF) was purified from culture filtrates of a T cell hybridoma, 23A4, by affinity chromatography on anti-lipomodulin Sepharose. The factor exhibited phospholipaseExpand
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Association of I-J determinants with lipomodulin/macrocortin.
Stimulation with glucocorticoids of mouse splenic lymphocytes and peritoneal adherent cells resulted in the formation of a soluble factor--i.e., glycosylation inhibiting factor (GIF)--that inhibitsExpand
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Activation of immune responses by muroctasin.
  • M. Akasaki
  • Chemistry, Medicine
  • Arzneimittel-Forschung
  • 1 July 1988
N2-[(N-Acetylmuramoyl)-L-alanyl-D-isoglutaminyl]-N6-stearoyl-L-lysine (MDP-Lys(L18), muroctasin), a muramyl dipeptide derivative, has been reported to enhance host resistance to infections, as wellExpand
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Gastric cytoprotection by ebselen against the injury induced by necrotizing agents in rats.
The gastric cytoprotective effect of ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one), a novel seleno-organic antioxidative agent, against the insults of necrotizing agents was investigated in rats.Expand
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Carrier-specific suppression of antibody responses by antigen-specific glycosylation-inhibiting factors.
We previously established an ovalbumin (OA)-specific T cell clone from spleen cells of BDF1 mice, which had been treated by i.v. injections of OA, and constructed antigen-specific T cell hybridomasExpand
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Modulation of the biologic activities of IgE-binding factors. VII. Biochemical mechanisms by which glycosylation-enhancing factor activates phospholipase in lymphocytes.
Cells of the T cell hybridoma 23A4 produce IgE-binding factors lacking N-linked oligosaccharides (unglycosylated form) when they are incubated with IgE alone. In the presence ofExpand
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T cell factors involved in the regulation of the IgE synthesis.
The IgE-potentiating and IgE-suppressive factors share a common structural gene and therefore a common polypeptide chain, and their biologic activities are decided by a post-translationalExpand
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