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Administration of CD34+ cells after stroke enhances neurogenesis via angiogenesis in a mouse model.
TLDR
It is demonstrated that systemic administration of human cord blood-derived CD34(+) cells to immunocompromised mice subjected to stroke 48 hours earlier induces neovascularization in the ischemic zone and provides a favorable environment for neuronal regeneration. Expand
Genotypes of vitamin K epoxide reductase, gamma-glutamyl carboxylase, and cytochrome P450 2C9 as determinants of daily warfarin dose in Japanese patients.
TLDR
GGCX 8016G>A, resulting in the missense mutation R325Q, is identified as a genetic determinant of warfarin maintenance dose in Japanese patients following ischemic stroke. Expand
Effect of Prothrombin Complex Concentrate on Hematoma Enlargement and Clinical Outcome in Patients with Anticoagulant-Associated Intracerebral Hemorrhage
TLDR
Immediate INR reversal with PCC may prevent HE and subsequent poor outcome and be associated with a reduction in poor clinical outcome in ICH patients whose INR values were above 2.0 on admission. Expand
Enlargement of spontaneous intracerebral hemorrhage. Incidence and time course.
TLDR
Although expansion of intracerebral hemorrhage on CT scan was common in the hyperacute stage, 17% of hematoma expansion occurred even after 6 hours of onset, early CT scanning appears to increase the rate of detection of enlarging hematomas. Expand
Effects of Extracranial–Intracranial Bypass for Patients With Hemorrhagic Moyamoya Disease: Results of the Japan Adult Moyamoya Trial
TLDR
Although statistically marginal, Kaplan–Meier analysis revealed the significant difference between surgical and nonsurgical group, suggesting the preventive effect of direct bypass against rebleeding. Expand
Prevention of rat cerebral aneurysm formation by inhibition of nitric oxide synthase.
TLDR
The evidence suggests that NO, particularly that derived from iNOS, is a key requirement for the development of cerebral aneurysm, and the iN OS induction may be caused by an increase in shear stress near the apex. Expand
Correction of INR by prothrombin complex concentrate and vitamin K in patients with warfarin related hemorrhagic complication.
TLDR
PCC administration with or without vitamin K seems to be more effective in rapidly correcting increased INR levels than vitamin K treatment without PCC, which may result in re-increase of INR and clinical deterioration. Expand
Takotsubo cardiomyopathy in acute ischemic stroke
TLDR
The aim of this study was to identify the clinical characteristics of acute ischemic stroke patients who experienced development of takotsubo cardiomyopathy. Expand
Predisposing factors for enlargement of intracerebral hemorrhage in patients treated with warfarin.
TLDR
An INR value of >2.0 within 24 h of ICH seems an important predisposing factor for ICH enlargement, which is similar to that shown in patients treated for intracerebral hematoma during warfarin therapy. Expand
Optimal dose of prothrombin complex concentrate for acute reversal of oral anticoagulation.
TLDR
The 500 IU of PCC is likely to be optimal dose of P CC for emergent reversal of INR in patients requiring rapid correction of InR below 5.0, but to be inadequate dose in patients with INR of 5. Expand
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