FAQ

drug binding

Known as: binding drug, binding drugs 
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1950-2017
020406019502016

Related topics

Related topics

4 relations
Blood Proteinsreceptor binding

Broader (2)

Drug Kineticsbiochemical mechanism

Related mentions per year

Related mentions per year

1937-2018
19401960198020002020
drug binding
Drug Kinetics
receptor binding
Blood Proteins
biochemical mechanism

Papers overview

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Highly Cited
2013
Highly Cited
2013
Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay.
The efficacy of therapeutics is dependent on a drug binding to its cognate target. Optimization of target engagement by drugs in… (More)
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2010
2010
Understanding and predicting druggability. A high-throughput method for detection of drug binding sites.
Druggability predictions are important to avoid intractable targets and to focus drug discovery efforts on sites offering better… (More)
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Highly Cited
2009
Highly Cited
2009
Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding.
P-glycoprotein (P-gp) detoxifies cells by exporting hundreds of chemically unrelated toxins but has been implicated in multidrug… (More)
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Highly Cited
2005
Highly Cited
2005
Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model.
We tested the hypothesis that microtubule (MT)-binding drugs could be therapeutically beneficial in tauopathies by functionally… (More)
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Highly Cited
2004
Highly Cited
2004
Physicochemical features of the HERG channel drug binding site.
Blockade of hERG K(+) channels in the heart is an unintentional side effect of many drugs and can induce cardiac arrhythmia and… (More)
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Highly Cited
2000
Highly Cited
2000
Communication between multiple drug binding sites on P-glycoprotein.
P-glycoprotein, a member of the ATP-binding cassette transporter family, is able to confer resistance on tumors against a large… (More)
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Highly Cited
1997
Highly Cited
1997
Positively cooperative sites for drug transport by P-glycoprotein with distinct drug specificities.
In this paper, we show that P-glycoprotein contains two distinct sites for drug binding and transport, and that, unexpectedly… (More)
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1997
1997
Sodium channel selectivity filter regulates antiarrhythmic drug binding.
Local anesthetic antiarrhythmic drugs block Na+ channels and have important clinical uses. However, the molecular mechanism by… (More)
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1995
1995
Prediction of drug binding affinities by comparative binding energy analysis.
A new computational method for deducing quantitative structure-activity relationships (QSARs) using structural data from ligand… (More)
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Highly Cited
1984
Highly Cited
1984
A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography.
We propose an in vivo method for use with positron emission tomography (PET) that results in a quantitative characterization of… (More)
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