drug binding

Known as: binding drug, binding drugs 
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1950-2017
020406019502016

Papers overview

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Highly Cited
2013
Highly Cited
2013
The efficacy of therapeutics is dependent on a drug binding to its cognate target. Optimization of target engagement by drugs in… (More)
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2010
2010
Druggability predictions are important to avoid intractable targets and to focus drug discovery efforts on sites offering better… (More)
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Highly Cited
2009
Highly Cited
2009
P-glycoprotein (P-gp) detoxifies cells by exporting hundreds of chemically unrelated toxins but has been implicated in multidrug… (More)
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Highly Cited
2005
Highly Cited
2005
We tested the hypothesis that microtubule (MT)-binding drugs could be therapeutically beneficial in tauopathies by functionally… (More)
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Highly Cited
2004
Highly Cited
2004
Blockade of hERG K(+) channels in the heart is an unintentional side effect of many drugs and can induce cardiac arrhythmia and… (More)
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Highly Cited
2000
Highly Cited
2000
P-glycoprotein, a member of the ATP-binding cassette transporter family, is able to confer resistance on tumors against a large… (More)
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Highly Cited
1997
Highly Cited
1997
In this paper, we show that P-glycoprotein contains two distinct sites for drug binding and transport, and that, unexpectedly… (More)
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1997
1997
Local anesthetic antiarrhythmic drugs block Na+ channels and have important clinical uses. However, the molecular mechanism by… (More)
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1995
1995
A new computational method for deducing quantitative structure-activity relationships (QSARs) using structural data from ligand… (More)
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Highly Cited
1984
Highly Cited
1984
We propose an in vivo method for use with positron emission tomography (PET) that results in a quantitative characterization of… (More)
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