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Differential effect of ethanol and hydrogen peroxide on barrier function and prostaglandin E2 release in differentiated Caco-2 cells: selective prevention by growth factors.
TLDR
Ethanol and H(2)O( 2) increased paracellular permeability in differentiated Caco-2 cells without affecting transcellular and active transport and growth factors, normally present in the intestine, exerted a selective protective effect toward parace cellular permeability increase induced by irritants. Expand
A new class of pseudopeptide antagonists of the kinin B1 receptor containing alkyl spacers.
TLDR
The analogue of desArg10-HOE 140 containing the 11-aminoundecanoic acid as spacer, MEN 11575, was found to be slightly more potent than the unmodified peptide and to represent a good template for the development of new peptidomimetic kinin B1 receptor antagonists. Expand
Observation of internal monosaccharide losses in the collisionally activated dissociation mass spectra of anthracycline aminodisaccharides
The loss of internal monosaccharide residues from anthracycline aminodisaccharides has been studied using high and low energy collisionally activated dissociations (CAD). The mass spectra and lowExpand
Mass spectrometry and combinatorial chemistry: a short outline.
TLDR
Some examples from the laboratory deal with the analysis of pooled oligomeric libraries containing n x 324 compounds, using both on-line high-performance liquid chromatography/MS with an ion trap mass spectrometer, and direct infusion into a triple quadrupole instrument. Expand
A Gαs Carboxyl-Terminal Peptide Prevents Gs Activation by the A2A Adenosine Receptor
TLDR
The results point out the conformation requirement of Gα s carboxyl-terminal peptides to modulate agonist binding to rat A 2A adenosine receptors and disrupt signal transduction. Expand
Impaired reinnervation in HIV infection following experimental denervation
TLDR
The results indicate that abnormalities in nerve regeneration occur early in HIV infection and provide a rationale to include neuropathy-free HIV subjects in regenerative peripheral nerve trials. Expand
Simultaneous LC-MS/MS determination of reference pharmaceuticals as a method for the characterization of the Caco-2 cell monolayer absorption properties.
TLDR
A unique LC-MS/MS method is used to simultaneously determine the Papp of a set of reference substances having well-characterized absorption behavior, i.e., phenylalanine, atenolol, and propranolol, which is routinely used in the laboratory to check on model reproducibility and proved useful in verifying the consistency of the results derived from the experiments. Expand
Enhancement of the Arthus reaction and suppression of delayed type hypersensitivity (DTH) by pluronic F-68, a detergent frequently used to prepare perfluorocarbon emulsions.
TLDR
The present data clearly demonstrate that the changes in Arthus reaction and the DTH response are due to the Pluronic F-68 used to emulsify the RM101 perfluorocarbon; the changes induced by the detergent in these two immune parameters probably involve separate mechanisms. Expand
Increased paracellular absorption by bile salts and P-glycoprotein stimulated efflux of otilonium bromide in Caco-2 cells monolayers as a model of intestinal barrier.
TLDR
Otilonium bromide is a paracellularly transported drug whose absorption, in amounts sufficient to exert a spasmolytic effect, is favoured by bile salts. Expand
The protective effect of aldrin against the toxicity of organophosphate anticholinesterases.
  • A. Triolo, J. Coon
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental…
  • 1 December 1966
TLDR
Though the increases in A- and B-esterases would be expected to decrease the toxicities of parathion and paraoxon, other factors possibly involving the central nervous system may play a role in aldrin's protective effect against organophosphate poisoning. Expand
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