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Inhibition of p38 MAPK Activation via Induction of MKP-1: Atrial Natriuretic Peptide Reduces TNF-&agr;–Induced Actin Polymerization and Endothelial Permeability
TLDR
The inhibitory action of ANP on TNF-&agr;–induced changes in endothelial cytoskeleton and macromolecule permeability involving an MKP-1–induced inactivation of p38 MAPK points to an antiinflammatory and antiatherogenic potential of this cardiovascular hormone. Expand
Cyclin-dependent Kinase 5 Regulates Endothelial Cell Migration and Angiogenesis
TLDR
It is shown that cyclin-dependent kinase 5 (Cdk5), an important modulator of neuronal processes, regulates endothelial cell migration and angiogenesis, suggesting Cdk5 as a novel target for antiangiogenic therapy. Expand
Atrial Natriuretic Peptide Induces Mitogen-Activated Protein Kinase Phosphatase-1 in Human Endothelial Cells via Rac1 and NAD(P)H Oxidase/Nox2-Activation
TLDR
In conclusion, this work provides insights into the mechanisms by which ANP induces MKP-1 and shows that ANP is a novel endogenous activator of endothelial Rac1 and Nox/Nox2. Expand
MAPK phosphatase‐1 represents a novel anti‐inflammatory target of glucocorticoids in the human endothelium
TLDR
MAPK phosphatase‐1 (MKP‐1) is identified as a pivotal mediator of the anti‐inflammatory action of glucocorticoids in the human endothelium and highlighted as an important and promising anti-inflammatory drug target. Expand
The Opioid Peptides Enkephalin and β-Endorphin in Alcohol Dependence
TLDR
Results indicate a contribution of beta-endorphin to ethanol consumption and dependence in humans and found a two-marker haplotype in the POMC gene that was associated with alcohol dependence in females in both cohorts. Expand
Perspective of Cyclin-dependent kinase 9 (CDK9) as a Drug Target
TLDR
This review discusses recent findings provided by structural biologists that may allow further development of highly specific inhibitors of CDK9 towards applications in cancer therapy and highlights the role ofCDK9 in inflammatory processes and diseases. Expand
Plant-Derived Anti-Inflammatory Compounds: Hopes and Disappointments regarding the Translation of Preclinical Knowledge into Clinical Progress
TLDR
This minireview will summarize the current situation of 6 very prominent plant-derived anti-inflammatory compounds: curcumin, colchicine, resveratrol, capsaicin, epigallocatechin-3-gallate (EGCG), and quercetin, and sum up the planned trials in order to provide insights into the inflammatory disorders that are hypothesized to be beneficially influenced by the compound. Expand
Pitfalls in assessing microvascular endothelial barrier function: impedance-based devices versus the classic macromolecular tracer assay
TLDR
The first direct comparison of these assays applied to one single cell type (human microvascular ECs) under the same experimental conditions concludes that the complementary combination of both approaches is highly recommended to overcome the restrictions of each assay. Expand
Linkage analysis using sex-specific recombination fractions with GENEHUNTER-MODSCORE
TLDR
The usage of sex-specific recombination frequencies in the GENEHUNTER-MODSCORE program that performs multipoint linkage analysis are implemented and a consistent method to choose the combinations of male and female genetic positions at which linkage scores should be calculated is devised. Expand
Linkage analysis of alcohol dependence using MOD scores
TLDR
The findings underscore the fact that an adequate modeling of the genotype-phenotype relation is crucial for the genetic mapping of a complex trait. Expand
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