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Molecular origin of cancer: catechol estrogen-3,4-quinones as endogenous tumor initiators.
- E. Cavalieri, D. Stack, +10 authors E. Rogan
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences…
- 30 September 1997
Cancer is a disease that begins with mutation of critical genes: oncogenes and tumor suppressor genes. Our research on carcinogenic aromatic hydrocarbons indicates that depurinating hydrocarbon-DNA… Expand
Phycobilisomes Supply Excitations to Both Photosystems in a Megacomplex in Cyanobacteria
Complexing Photosynthesis Photosynthesis operates through a series of protein complexes that harvest sunlight and turn it into chemical energy. The separate complexes—including photosystems I and II,… Expand
Molecular mechanism of photoactivation and structural location of the cyanobacterial orange carotenoid protein.
The orange carotenoid protein (OCP) plays a photoprotective role in cyanobacterial photosynthesis similar to that of nonphotochemical quenching in higher plants. Under high-light conditions, the OCP… Expand
Ionic liquids as matrixes for matrix-assisted laser desorption/ionization mass spectrometry.
Room-temperature ionic liquids are useful as solvents for organic synthesis, electrochemical studies, and separations. We wished to examine whether their high solubalizing power, negligible vapor… Expand
Proteins under pressure
Oceans not only cover the major part of the earth’s surface but also reach into depths exceeding the height of the Mt Everest. They are populated down to the deepest levels (≈11800 m), which means… Expand
Laser flash photolysis of hydrogen peroxide to oxidize protein solvent-accessible residues on the microsecond timescale
Footprinting of proteins by hydroxyl radicals generated on the millisecond to minute timescales to probe protein surfaces suffers from the uncertainty that radical reactions cause the protein to… Expand
Metabolism and DNA binding studies of 4-hydroxyestradiol and estradiol-3,4-quinone in vitro and in female ACI rat mammary gland in vivo.
Studies of estrogen metabolism, formation of DNA adducts, carcinogenicity, cell transformation and mutagenicity have led to the hypothesis that reaction of certain estrogen metabolites, predominantly… Expand
Gas-phase stability of double-stranded oligodeoxynucleotides and their noncovalent complexes with DNA-binding drugs as revealed by collisional activation in an ion trap
- K. X. Wan, M. Gross, T. Shibue
- Medicine, Chemistry
- Journal of the American Society for Mass…
- 1 May 2000
The intrinsic (gas-phase) stabilities of duplex, self-complementary oligonucleotides were measured in a relative way by subjecting the duplex precursor ions to increasing amounts of collision energy… Expand
Psb27, a transiently associated protein, binds to the chlorophyll binding protein CP43 in photosystem II assembly intermediates
- H. Liu, R. Huang, J. Chen, M. Gross, H. Pakrasi
- Medicine, Biology
- Proceedings of the National Academy of Sciences
- 26 October 2011
Photosystem II (PSII), a large multisubunit pigment–protein complex localized in the thylakoid membrane of cyanobacteria and chloroplasts, mediates light-driven evolution of oxygen from water.… Expand
Fourier transform mass spectrometry.
Fourier transform mass spectrometry will play an important role in the future because of its unique combination of high mass resolution, high upper mass limit, and multichannel advantage. These… Expand