drotrecogin alfa

Known as: Revombinant Human Autoprothrombin IIA, Activated, DROTRECOGIN ALFA (ACTIVATED), Drotrecogin alfa (activated), lyophilized 
A recombinant form of human protein C with anti-thrombotic, anti-inflammatory, and profibrinolytic properties.
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
BACKGROUND There have been conflicting reports on the efficacy of recombinant human activated protein C, or drotrecogin alfa… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND In patients with chronic infection with hepatitis C virus (HCV) genotype 1, treatment with peginterferon alfa and… (More)
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Highly Cited
2008
Highly Cited
2008
OBJECTIVE To provide an update to the original Surviving Sepsis Campaign clinical management guidelines, "Surviving Sepsis… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND Drotrecogin alfa (activated) (DrotAA) is used for the treatment of adults with severe sepsis who have a high risk of… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND In November 2001, the Food and Drug Administration (FDA) approved drotrecogin alfa (activated) (DrotAA) for adults who… (More)
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Highly Cited
2005
Highly Cited
2005
OBJECTIVE To provide further evidence for the efficacy and safety of drotrecogin alfa (activated) treatment in severe sepsis… (More)
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Highly Cited
2004
Highly Cited
2004
Disseminated intravascular coagulation (DIC) is a serious condition associated with sepsis. Clinical management of DIC is… (More)
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Highly Cited
2003
Highly Cited
2003
OBJECTIVE To assess the effects of drotrecogin alfa (activated) therapy, a recombinant human activated protein C, across… (More)
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Highly Cited
2003
Highly Cited
2003
OBJECTIVE To assess morbidity in patients with severe sepsis managed with and without drotrecogin alfa (activated). DESIGN… (More)
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Highly Cited
2001
Highly Cited
2001
BACKGROUND Drotrecogin alfa (activated), or recombinant human activated protein C, has antithrombotic, antiinflammatory, and… (More)
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