Skip to search formSkip to main contentSkip to account menu

drotrecogin alfa

Known as: Revombinant Human Autoprothrombin IIA, Activated, DROTRECOGIN ALFA (ACTIVATED), Drotrecogin alfa (activated), lyophilized 
A recombinant form of human protein C with anti-thrombotic, anti-inflammatory, and profibrinolytic properties.
National Institutes of Health

Related topics

Related topics

14 relations

Broader (2)

Anti-Infective AgentsProtein C
Brain NeoplasmsCerebral InfarctionCerebrovascular TraumaDrug Allergy

Narrower (1)

rhAPC

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Endogenous activated protein C limits cancer cell extravasation through sphingosine-1-phosphate receptor 1-mediated vascular endothelial barrier enhancement.
Activated protein C (APC) has both anticoagulant activity and direct cell-signaling properties. APC has been reported to promote… 
Highly Cited
2009
Highly Cited
2009
Protection of vascular barrier integrity by activated protein C in murine models depends on protease-activated receptor-1
Summary Protease activated receptor-1 (PAR1) mediates barrier protective signalling of activated protein C (APC) in human… 
Review
2007
Review
2007
Evaluating the use of Drotrecogin alfa (activated) in adult severe sepsis: a Canadian multicenter observational study
BackgroundThe purpose of this study was to characterize the usage patterns and clinical outcomes of DAA in Ontario and Quebec… 
Highly Cited
2002
Highly Cited
2002
Comparison of the isoelectric focusing patterns of darbepoetin alfa, recombinant human erythropoietin, and endogenous erythropoietin from human urine.
Novel erythropoiesis-stimulating protein (AranespTM; darbepoetin alfa) is a glycoprotein hormone with a longer serum half-life… 
Highly Cited
1993
Highly Cited
1993
Role of the membrane in the inactivation of factor Va by activated protein C.
Highly Cited
1991
Highly Cited
1991
Functionally active protein C inhibitor/plasminogen activator inhibitor-3 (PCI/PAI-3) is secreted in seminal vesicles, occurs at high concentrations in human seminal plasma and complexes with…
Highly Cited
1988
Highly Cited
1988
Physiologic inhibition of human activated protein C by alpha 1-antitrypsin.
Highly Cited
1986
Highly Cited
1986
Cultured bovine aortic endothelial cells promote activated protein C-protein S-mediated inactivation of factor Va.
Previous studies have demonstrated that protein S is required for optimal activated protein C-mediated inactivation of Factor Va… 
Highly Cited
1982
Highly Cited
1982
Studies of the capacity of factor Xa to protect factor Va from inactivation by activated protein C.
Highly Cited
1979
Highly Cited
1979
Activated protein C inhibits platelet prothrombin-converting activity.
Bovine platelets that have been activated by thrombin facilitate the conversion of prothrombin to thrombin in the presence of… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)