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A Model for the Stoichiometric Regulation of Blood Coagulation*
We have developed a model of the extrinsic blood coagulation system that includes the stoichiometric anticoagulants. The model accounts for the formation, expression, and propagation of the vitaminExpand
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The dynamics of thrombin formation.
The central event of the hemostatic process is the generation of thrombin through the tissue factor pathway. This is a highly regulated, dynamic process in which thrombin itself plays many roles,Expand
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Surface-dependent reactions of the vitamin K-dependent enzyme complexes.
During the past 20 years contributions from many laboratories have led to the development of isolation procedures, delineation of primary structures, and more recently, to the expression ofExpand
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The mechanism of inactivation of human factor V and human factor Va by activated protein C.
The cleavage of human factor V and human factor Va by human activated protein C (APC) was analyzed in the absence and presence of phospholipid vesicles containing 75% phosphatidylcholine (PC) and 25%Expand
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Platelet function monitoring in patients with coronary artery disease.
Studies focused on patient responsiveness to antiplatelet therapies, particularly aspirin and clopidogrel, have increased in recent years. However, the relations of in vivo platelet function andExpand
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Biochemistry and physiology of blood coagulation.
  • K. Mann
  • Medicine
  • Thrombosis and haemostasis
  • 1 August 1999
Introduction: The biochemical investigation of a biological process can be divided into three segments. The first is the development of an inventory of the components involved in the process, theExpand
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"Normal" thrombin generation.
We have investigated the influence of alterations in plasma coagulation factor levels between 50% and 150% of their mean values for prothrombin, factor X, factor XI, factor IX, factor VII, factorExpand
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Thromboelastography as a better indicator of hypercoagulable state after injury than prothrombin time or activated partial thromboplastin time.
OBJECTIVES To investigate the hemostatic status of critically ill, nonbleeding trauma patients. We hypothesized that a hypercoagulable state exists in patients early after severe injury and that theExpand
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Statins and Blood Coagulation
The 3-hydroxy-3-methylglutaryl (HMG)-coenzyme A (CoA) reductase inhibitors (statins) have been shown to exhibit several vascular protective effects, including antithrombotic properties, that are notExpand
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Factor V: a combination of Dr Jekyll and Mr Hyde.
The desirable process of hemostasis and the undesirable phenomena of thromboses are unequivocally consequences of the generation of thrombin by the prothrombinase complex. This stoichiometric complexExpand
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