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Endothelial cells in physiology and in the pathophysiology of vascular disorders.
THE ENDOTHELIUM has long been viewed as an inert cellophane-like membrane that lines the circulatory system with its primary essential function being the maintenance of vessel wall permeability.Expand
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Understanding RAGE, the receptor for advanced glycation end products
Advanced glycation end products (AGEs), S100/calgranulins, HMGB1-proteins, amyloid-β peptides, and the family of β-sheet fibrils have been shown to contribute to a number of chronic diseases such asExpand
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Blockade of RAGE–amphoterin signalling suppresses tumour growth and metastases
The receptor for advanced glycation end products (RAGE), a multi-ligand member of the immunoglobulin superfamily of cell surface molecules, interacts with distinct molecules implicated inExpand
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The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses.
The multiligand receptors that form the focus of this Perspective series have expectedly diverse functions, often conforming to potential gaps in the host response to invading pathogens that are notExpand
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Activation of NADPH oxidase by AGE links oxidant stress to altered gene expression via RAGE.
Engagement of the receptor for advanced glycation end products (RAGE) by products of nonenzymatic glycation/oxidation triggers the generation of reactive oxygen species (ROS), thereby altering geneExpand
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The Receptor for Advanced Glycation End Products (RAGE) Is a Cellular Binding Site for Amphoterin
The receptor for advanced glycation end products (RAGE), a newly-identified member of the immunoglobulin superfamily, mediates interactions of advanced glycation end product (AGE)-modified proteinsExpand
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The N-terminal domain of thrombomodulin sequesters high-mobility group-B1 protein, a novel antiinflammatory mechanism.
Thrombomodulin (TM) is an endothelial anticoagulant cofactor that promotes thrombin-mediated formation of activated protein C (APC). We have found that the N-terminal lectin-like domain (D1) of TMExpand
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Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response.
While the initiation of the adaptive and innate immune response is well understood, less is known about cellular mechanisms propagating inflammation. The receptor for advanced glycation end productsExpand
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Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB.
Activation of the transcription factor nuclear factor-kappaB (NF-kappaB) has been suggested to participate in chronic disorders, such as diabetes and its complications. In contrast to the short andExpand
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The biology of the receptor for advanced glycation end products and its ligands.
Receptor for advanced glycation end products (RAGE) is a multiligand member of the immunoglobulin superfamily of cell surface molecules whose repertoire of ligands includes advanced glycation endExpand
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