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docetaxel

Known as: docetaxel hydrate, [2aR-[2a Alphaa,4beta,4a beta,6beta,9alpha,(alphaR*,betaS*),-11alpha,12alpha,12a alpha,12b alpha]]-beta-[[(1,1-dimethylethoxy)carbonyl]-amino]-alpha-hydroxybenzemepropanoic Acid 12b-(Acetyloxy)-12(benzyloxy)-2a,3,4,4a,5,6,8,10,11,12,12a,12b-dodecahydeo-4,-6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester, docetaxol 
A semi-synthetic, second-generation taxane derived from a compound found in the European yew tree, Taxus baccata. Docetaxel displays potent and broad… 
National Institutes of Health

Related topics

Related topics

41 relations
1 ML docetaxel 20 MG/ML Injection [Taxotere]Ad5CMV-p53 gene/docetaxel/doxorubicinApoptosisBCL2 protein, human

Broader (2)

Antineoplastic AgentsTaxoids

Narrower (6)

DOCETAXEL ANHYDROUSNSC 628503RP 56976RP56976

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Detection of JWH-018 metabolites in smoking mixture post-administration urine.
Highly Cited
2007
Highly Cited
2007
Addition of estramustine to chemotherapy and survival of patients with castration-refractory prostate cancer: a meta-analysis of individual patient data.
Highly Cited
2006
Highly Cited
2006
Bevacizumab and weekly taxane chemotherapy demonstrates activity in refractory ovarian cancer.
Highly Cited
2005
Highly Cited
2005
Neoadjuvant Docetaxel before Radical Prostatectomy in Patients with High-Risk Localized Prostate Cancer
Purpose: To determine the clinical, pathologic, and molecular effects of neoadjuvant docetaxel chemotherapy in high-risk… 
Highly Cited
2004
Highly Cited
2004
Comparative Pharmacokinetics of Weekly and Every-Three-Weeks Docetaxel
Purpose: Weekly administration of docetaxel has demonstrated comparable efficacy together with a distinct toxicity profile with… 
Highly Cited
2000
Highly Cited
2000
Biodistribution of paclitaxel and poly(l-glutamic acid)-paclitaxel conjugate in mice with ovarian OCa-1 tumor
Purpose: Poly(l-glutamic acid)-paclitaxel (PG-TXL) is a water-soluble paclitaxel (TXL) conjugate made by conjugating TXL to poly… 
Highly Cited
1999
Highly Cited
1999
Antitumor activity of poly(L-glutamic acid)-paclitaxel on syngeneic and xenografted tumors.
Poly(L-glutamic acid)-paclitaxel (PG-TXL) is a new water-soluble paclitaxel derivative that has shown remarkable antitumor… 
Review
1998
Review
1998
Preclinical pharmacokinetics of paclitaxel and docetaxel.
The taxanes paclitaxel and docetaxel represent a novel class of antineoplastic agents. A major problem of both drugs is their low… 
Highly Cited
1998
Highly Cited
1998
Phase I study of docetaxel with concomitant thoracic radiation therapy.
PURPOSE The taxanes have demonstrated activity as radiation sensitizers in preclinical studies. This study was designed to… 
Highly Cited
1994
Highly Cited
1994
Phase II trial of docetaxel in patients with platinum-refractory advanced ovarian cancer.
PURPOSE This phase II study was conducted to evaluate the efficacy and toxicity of docetaxel in the treatment of patients with… 
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