dihydrofolate
National Institutes of Health
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Abstract Recent advances in microbial genomics, synthetic organic chemistry and X-ray crystallography provided opportunities to…
The thermodynamics and kinetics of the interaction of dihydrofolate reductase (DHFR) with methotrexate have been studied by using…
Increasing resistance of Plasmodium falciparum malaria parasites to chloroquine and the dihydrofolate reductase (DHFR) inhibitors…
Single and multiple mutations at residues 16, 51, 59, 108, and 164 of Plasmodium falciparum dihydrofolate reductase (pfDHFR) have…
To facilitate genetic analysis of the protozoan parasite Toxoplasma gondii, sequences derived from the parasite's fused…
Back propagation neural networks is a new technology useful for modeling nonlinear functions of several variables. This paper…
Analysis of a genetic cross of Plasmodium falciparum and of independent parasite isolates from Southeast Asia, Africa, and South…
A kinetic scheme is presented for Escherichia coli dihydrofolate reductase that predicts steady-state kinetic parameters and full…
We have constructed a cDNA library from a murine cell line expressing high levels of a dihydrofolate reductase (tetrahydrofolate…
X-ray data have been extended to 1.7 A for a binary complex of Escherichia coli dihydrofolate reductase with methotrexate and a…