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dihydrofolate

 
National Institutes of Health

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Highly Cited
2007
Highly Cited
2007
Alternative promoters within the same gene are a general phenomenon in gene expression. Mechanisms of their selective regulation… Expand
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Highly Cited
2007
Highly Cited
2007
MicroRNAs are predicted to regulate ≈30% of all human genes by targeting sequences in their 3′ UTR. Polymorphisms in 3′ UTR of… Expand
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Highly Cited
2006
Highly Cited
2006
We used nuclear magnetic resonance relaxation dispersion to characterize higher energy conformational substates of Escherichia… Expand
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Review
2004
Review
2004
Molecular motions are widely regarded as contributing factors in many aspects of protein function. The enzyme dihydrofolate… Expand
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Highly Cited
1997
Highly Cited
1997
The reaction catalyzed by Escherichia coli dihydrofolate reductase (ecDHFR) cycles through five detectable kinetic intermediates… Expand
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Highly Cited
1997
Highly Cited
1997
Single and multiple mutations at residues 16, 51, 59, 108, and 164 of Plasmodium falciparum dihydrofolate reductase (pfDHFR) have… Expand
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Highly Cited
1988
Highly Cited
1988
A study of the binding of the antibacterial agent trimethoprim to Escherichia coli dihydrofolate reductase was carried out using… Expand
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Highly Cited
1988
Highly Cited
1988
Analysis of a genetic cross of Plasmodium falciparum and of independent parasite isolates from Southeast Asia, Africa, and South… Expand
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Highly Cited
1987
Highly Cited
1987
A kinetic scheme is presented for Escherichia coli dihydrofolate reductase that predicts steady-state kinetic parameters and full… Expand
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Highly Cited
1978
Highly Cited
1978
The rate of dihydrofolate reductase synthesis in the AT3000 line of methotrexate-resistant murine Sarcoma 180 cells is… Expand
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