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dihydrofolate

National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
Alternative promoters within the same gene are a general phenomenon in gene expression. Mechanisms of their selective regulation… 
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Highly Cited
2007
Highly Cited
2007
MicroRNAs are predicted to regulate ≈30% of all human genes by targeting sequences in their 3′ UTR. Polymorphisms in 3′ UTR of… 
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Highly Cited
2006
Highly Cited
2006
We used nuclear magnetic resonance relaxation dispersion to characterize higher energy conformational substates of Escherichia… 
Review
2004
Review
2004
Molecular motions are widely regarded as contributing factors in many aspects of protein function. The enzyme dihydrofolate… 
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Highly Cited
1997
Highly Cited
1997
The reaction catalyzed by Escherichia coli dihydrofolate reductase (ecDHFR) cycles through five detectable kinetic intermediates… 
Review
1995
Review
1995
As chloroquine resistance spreads across Africa, the dihydrofolate reductase (DHFR) inhibitors pyrimethamine and proguanil are… 
Highly Cited
1988
Highly Cited
1988
A study of the binding of the antibacterial agent trimethoprim to Escherichia coli dihydrofolate reductase was carried out using… 
Highly Cited
1988
Highly Cited
1988
Analysis of a genetic cross of Plasmodium falciparum and of independent parasite isolates from Southeast Asia, Africa, and South… 
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Highly Cited
1987
Highly Cited
1987
A kinetic scheme is presented for Escherichia coli dihydrofolate reductase that predicts steady-state kinetic parameters and full… 
Highly Cited
1978
Highly Cited
1978
The rate of dihydrofolate reductase synthesis in the AT3000 line of methotrexate-resistant murine Sarcoma 180 cells is… 
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