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dihydrofolate

National Institutes of Health

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5 relations
7,8-dihydrofolic acidDihydrofolate:MCnc:Pt:Ser:Qnanalogs & derivatives

Broader (1)

Folic Acid

Narrower (1)

dihydrofolate reductase activity

Papers overview

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Highly Cited
1992
Highly Cited
1992
The HIP1 binding site is required for growth regulation of the dihydrofolate reductase gene promoter
The transcription rate of the dihydrofolate reductase (DHFR) gene increases at the G1/S boundary of the proliferative cell cycle… 
Highly Cited
1990
Highly Cited
1990
Stereochemical mechanism of action for thymidylate synthase based on the X-ray structure of the covalent inhibitory ternary complex with 5-fluoro-2'-deoxyuridylate and 5,10-methylenetetrahydrofolate.
Highly Cited
1986
Highly Cited
1986
Expression, purification, and characterization of recombinant gamma-carboxylated factor IX synthesized in Chinese hamster ovary cells.
Highly Cited
1986
Highly Cited
1986
Transcription factor Sp1 recognizes a DNA sequence in the mouse dihydrofolate reductase promoter
Human (HeLa) cells contain a host-cell-encoded transcription factor, Sp1, which is required for transcription of simian virus 40… 
Highly Cited
1983
Highly Cited
1983
Enhancement of methotrexate resistance and dihydrofolate reductase gene amplification by treatment of mouse 3T6 cells with hydroxyurea
We investigated various parameters associated with the initial selection of mouse 3T6 cells for resistance to single… 
Highly Cited
1981
Highly Cited
1981
Phorbol ester dramatically increases incidence of methotrexate-resistant mouse cells: Possible mechanisms and relevance to tumor promotion
Highly Cited
1981
Highly Cited
1981
The influence of methotrexate pretreatment on 5-fluorouracil metabolism in L1210 cells.
Highly Cited
1981
Highly Cited
1981
Amplification and loss of dihydrofolate reductase genes in a Chinese hamster ovary cell line
During stepwise increases in the methotrexate concentration in culture medium, we selected Chinese hamster ovary cells that… 
Highly Cited
1981
Highly Cited
1981
Transformation of mouse fibroblasts to methotrexate resistance by a recombinant plasmid expressing a prokaryotic dihydrofolate reductase.
A recombinant plasmid has been constructed for the expression of inserted DNA sequences coding for polypeptide chains using the… 
Highly Cited
1979
Highly Cited
1979
Biochemical determinants of tumor sensitivity to 5-fluorouracil: ultrasensitive methods for the determination of 5-fluoro-2'-deoxyuridylate, 2'-deoxyuridylate, and thymidylate synthetase.
Techniques have been developed to measure FdUMP, the active metabolite of 5-FUra; thymidylate synthetase (TMP synthase; 5,10… 
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