dihydrofolate
National Institutes of Health
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Alternative promoters within the same gene are a general phenomenon in gene expression. Mechanisms of their selective regulation…
MicroRNAs are predicted to regulate ≈30% of all human genes by targeting sequences in their 3′ UTR. Polymorphisms in 3′ UTR of…
We used nuclear magnetic resonance relaxation dispersion to characterize higher energy conformational substates of Escherichia…
Molecular motions are widely regarded as contributing factors in many aspects of protein function. The enzyme dihydrofolate…
The reaction catalyzed by Escherichia coli dihydrofolate reductase (ecDHFR) cycles through five detectable kinetic intermediates…
Increasing resistance of Plasmodium falciparum malaria parasites to chloroquine and the dihydrofolate reductase (DHFR) inhibitors…
As chloroquine resistance spreads across Africa, the dihydrofolate reductase (DHFR) inhibitors pyrimethamine and proguanil are…
A study of the binding of the antibacterial agent trimethoprim to Escherichia coli dihydrofolate reductase was carried out using…
Analysis of a genetic cross of Plasmodium falciparum and of independent parasite isolates from Southeast Asia, Africa, and South…
The rate of dihydrofolate reductase synthesis in the AT3000 line of methotrexate-resistant murine Sarcoma 180 cells is…