dihydrofolate

 
National Institutes of Health

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Highly Cited
2007
Highly Cited
2007
Alternative promoters within the same gene are a general phenomenon in gene expression. Mechanisms of their selective regulation… (More)
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Highly Cited
2006
Highly Cited
2006
We used nuclear magnetic resonance relaxation dispersion to characterize higher energy conformational substates of Escherichia… (More)
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Highly Cited
2005
Highly Cited
2005
Recent studies demonstrate that oxidative inactivation of tetrahydrobiopterin (H4B) may cause uncoupling of endothelial nitric… (More)
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Review
2004
Review
2004
Molecular motions are widely regarded as contributing factors in many aspects of protein function. The enzyme dihydrofolate… (More)
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Highly Cited
1998
Highly Cited
1998
Reassembly of enzymes from peptide fragments has been used as a strategy for understanding the evolution, folding, and role of… (More)
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Highly Cited
1997
Highly Cited
1997
Increasing resistance of Plasmodium falciparum malaria parasites to chloroquine and the dihydrofolate reductase (DHFR) inhibitors… (More)
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Highly Cited
1997
Highly Cited
1997
The reaction catalyzed by Escherichia coli dihydrofolate reductase (ecDHFR) cycles through five detectable kinetic intermediates… (More)
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Highly Cited
1988
Highly Cited
1988
Analysis of a genetic cross of Plasmodium falciparum and of independent parasite isolates from Southeast Asia, Africa, and South… (More)
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Highly Cited
1988
Highly Cited
1988
A study of the binding of the antibacterial agent trimethoprim to Escherichia coli dihydrofolate reductase was carried out using… (More)
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Highly Cited
1978
Highly Cited
1978
The rate of dihydrofolate reductase synthesis in the AT3000 line of methotrexate-resistant murine Sarcoma 180 cells is… (More)
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