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dihydrofolate reductase activity

Known as: 7,8-dihydrofolate reductase activity, dihydrofolic acid reductase activity, dihydrofolate reduction 
Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+. [EC:1.5.1.3]
National Institutes of Health

Related topics

Related topics

3 relations
Dihydrofolate Reductase, humanTetrahydrofolate Dehydrogenase

Broader (1)

dihydrofolate

Papers overview

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2004
2004
Dihydrofolate reductase activity and resistance to aminopterin in various species of Drosophila
SummaryThe aim of our work was to compare the mechanisms of resistance to aminopterin, inhibitor of the dihydrofolate reductase… 
1989
1989
Sequence-dependent enhancement of HCT-8 cell kill by trimetrexate and fluoropyrimidines: implications for the mechanism of this interaction.
1981
1981
Isolation and characterization of dihydrofolic acid reductase from methotrexate-sensitive and -resistant human cell lines.
Dihydrofolic acid reductase has been purified by affinity chromatography to apparent homogeneity from the human HeLa BU-25 cell… 
1978
1978
Trimethoprim-induced elevation of dihydrofolate reductase activity in human leukocytes.
The administration of trimethoprim (TMP)--a diamino benzylpyrimidine compound which binds very tightly the bacterial… 
1972
1972
Dihydrofolate Reductase Activity in Strains of Streptococcus faecium var. durans Resistant to Methasquin and Amethopterin
Resistance to the antifolates methasquin and amethopterin has been studied in new strains of Streptococcus faecium var. durans… 
1968
1968
Triamterene-induced elevation of dihydrofolate reductase activity in human leukocytes.
1967
1967
Effect of triamterene on folic reductase activity and reproduction in the rat.
1967
1967
The effect of treatment with cytotoxic agents on mouse spleen dihydrofolate reductase activity.
Daily treatment of mice with 0.8 mg methotrexate/kg/day for 14 days led to a transient splenic hyperplasia and increased spleen… 
1964
1964
STUDIES ON FOLIC REDUCTASE. I. LEVELS IN REGENERATING RAT LIVER AND THE EFFECT OF METHOTREXATE ADMINISTRATION.
The folic reductase activity of regenerating rat liver remained normal or dropped slightly during the first 72 hours following… 
1964
1964
FURTHER OBSERVATIONS OF THE BINDING AND INHIBITION OF DIHYDROFOLIC REDUCTASE BY FOLIC ACID ANTAGONISTS.
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