• Publications
  • Influence
Trimethoprim, a sulphonamide potentiator.
  • 348
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A comparison of the specificities of xanthine oxidase and aldehyde oxidase.
Abstract This study directly compares the specificities of the structurally similar hydroxylating enzymes, aldehyde oxidase and xanthine oxidase. Michaelis-Menten constants for a variety ofExpand
  • 312
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Metabolic studies of allopurinol, an inhibitor of xanthine oxidase.
Abstract The metabolic disposition of allopurinol [4-hydroxypyrazolo(3,4-d)-pyrimidine) was determined in mice, dogs, and human subjects. The drug is a substrate for, as well as an inhibitor of,Expand
  • 293
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Potentiation by inhibition of drug degradation : 6-substituted purines and xanthine oxidase
Abstract The administration of the xanthine oxidase inhibitor. 4-hydroxypyrazolo (3, 4-d)pyrimidine, concurrently with 6-mercaptopurine, results in a marked decrease in the metabolic oxidation of theExpand
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Inhibition of folate biosynthesis and function as a basis for chemotherapy.
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Plasmodium berghei dihydrofolate reductase. Isolation, properties, and inhibition by antifolates.
Dihydrofolate reductase has been isolated from cells of the rodent malarial organism Plasmodium berghei by separation from the host cells with saponin and extraction by rupture in a French pressureExpand
  • 157
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Mechanism of action of trimethoprim-sulfamethoxazole. I.
  • G. Hitchings
  • Chemistry, Medicine
  • The Journal of infectious diseases
  • 1 November 1973
Tetrahydrofolate (FAH4) participates in biosynthetic reactions that are vital to cellular growth and survival. In microorganisms, dihydrofolate (FAH2) is synthesized de novo from p-aminobenzoic acid.Expand
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The Synthesis of 6-Thioguanine
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